DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and mthl4

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	122/526 - (23%)
Similarity:	211/526 - (40%)	Gaps:	122/526 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPD 177
            |.|....|.:|     :....|.||: |:.|..|:  |:....:::..::. :||:...|.....
  Fly    21 PGCDFFDTVDI-----SKAPRFSNGS-YLYEGLLI--PAHLTAEYDYKLLA-DDSKEKVASHVRG 76

  Fly   178 YAAN--PLVQQEPPK-ASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRLSPQLPEGS--- 236
            .|.:  |.::...|: ..::.|||.|            |:..:.....|..:.::  |.:||
  Fly    77 CACHLRPCIRFCCPQYQKMQKSKCYG------------DMSEDELNKHDPFVNVT--LSDGSVVR 127

  Fly   237 --------YQTSYGLPDCGQ--------PGGYSIAGDWQDAKLDRNTAMLQLPHK-NLSAGQYCL 284
                    .|:....|.|.:        ||        .:..|..|.::|:...| .||..:||:
  Fly   128 RHFKEDLIVQSDLAKPGCPRMYFLNHELPG--------NEFTLFENGSLLRHWDKVELSKREYCV 184

  Fly   285 EHTQ-REGEVKI------IACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVF 342
            :|.. ::..::|      ::.:|                           .:...|..|::|::.
  Fly   185 QHLSFKDDSIRIAPHFCPLSSEH---------------------------SRTWKTVAIVISLIC 222

  Fly   343 LSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFL 407
            :..| ::.:|.......||.:|.|||:..|..|...|.:.....|    |..|.|......|..:
  Fly   223 IILT-ISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLNVWKYS----SGFCVTAGFLGYFSVM 282

  Fly   408 AAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYL-------YSLYAWGGPLLITFVAACVDQL 465
            ||||||:.:..::...|      ||..|  .|.|.|       |:|||||.||::|.:....||:
  Fly   283 AAFFWLSVIGIHLRIKF------SLASN--CLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQV 339

  Fly   466 PETTLLRP--GFGQLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQL------TCGLWKR 522
            .:...|||  |.|: .||....::::..|||||:.||:..||.:||.:...:      ..||..:
  Fly   340 VKNEKLRPRVGVGK-NCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHK 403

  Fly   523 DDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGVW----FFTDLINALQGVFIFIVV 583
            ...........:..:.|:|.::||::|..:|||:|: .....|    ...|..|..||..||::.
  Fly   404 QQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLL-TKQQAWARALMVADYFNWSQGTIIFVLF 467

  Fly   584 GCQPQV 589
            ..:|.:
  Fly   468 ILKPSI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	77/268 (29%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	40/208 (19%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	60/185 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_KOG4193
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.820