Protein Alignment mthl1 and mthl14

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 603
• Identity: 118/603 - (19%)
• Similarity: 213/603 - (35%)
• Gaps: 161/603 - (26%)

  Fly    82 WLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGANVMLFPNGTLYVRERAL 146
            |..::.|:..|.||   .||.:    :.....:.:....:.||...     .|.:.::.|.:.::
  Fly     6 WNFLLALISLQTFF---NASAQ----ISTVNNSSKGSNNSNIFHED-----TFNSTSIDVLDASI 58

  Fly   147 ---MVQPSDYCVDWEVAVVC---LNDSQPI-----NALEDPDYAANPLVQQEP-PKASLRLSKCC 199
               :|.|..|..  |.|.:.   ...|.|:     |.|:..|.:.....:::| ...|.||.|||
  Fly    59 HSTLVVPQTYST--EAATISGARFATSVPVQSPVDNPLDPADCSQREKYRKQPVATPSSRLRKCC 121

  Fly   200 GKWGSYNTQLQN-----CDLQPNHQAAVDGLLRLSPQ----------LPEGSYQTSYGLPDCGQP 249
            ....:.|...:|     ||         :|||...|.          :.:...:|:... |.|.|
  Fly   122 PHGENLNIYRENQSDSMCD---------NGLLSFEPTIISAVLFDNCIEDLEVETTLDY-DIGNP 176

  Fly   250 GGYSIAGD--------WQDAKL---DR--NTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQHL 301
            ...|:..|        .||..|   |:  |.:.....|       |||: ..:.|        ||
  Fly   177 CNSSLLYDDKDDVFFVLQDGSLLIIDKFGNESYTVKEH-------YCLD-IDKSG--------HL 225

  Fly   302 FSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVH--HALHWRC 364
            |:...            :.|...|.....|:...:|: ::.:...|:..:|...:.  ..||...
  Fly   226 FAFTC------------VTQVEEQIAFAKVVFVAVLM-LISMPCLLLVSYLHMTLRLLRNLHGLS 277

  Fly   365 QICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCF----NIWWTFR 425
            ......||..|..:.::..:......|     .:...:||..|:.|||...:||    |:|:..
  Fly   278 LSLMSLCLASGYFVHSVVHIYGIPNQG-----FIGYVIQFCILSYFFWYLCICFNVLLNVWYKL- 336

  Fly   426 DFRPSSLE--RNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWF------ 482
               |..::  ::........|:::|:.||  .|.||..|.:         |...:..:|
  Fly   337 ---PCCIQCSKSWATFNFACYAVFAFSGP--ATIVALTVQK---------GLPGMPSYFLQGLTE 387

  Fly   483 ---DNRNLSIFAYFYGPIGLLLCANIALFV----------------STTHQLTC--GLWKRDDVK 526
               |::.     ||..|:..:|..:..|.:                ....:..|  ...|.:|||
  Fly   388 SIRDSQR-----YFIPPVSTILFLSFLLNIISFFGFQRISGYAKAEKNIQERKCLFDQQKYEDVK 447

  Fly   527 SSSEKSALGRVCLKLV-VVMGVTWIADILSWLVGGPHGVWFFTDLINALQGVFIFIVVGCQPQVW 590
            ..::       |:.|: ::|.|:|:.:|:::..|.........|::|.||||::.::.....:..
  Fly   448 KDAK-------CVSLLGIIMVVSWLLEIITFYSGSNSNYLILCDMVNGLQGVWVLLIFLVVRRRR 505

  Fly   591 TACRRIFCPRLRHDITNT 608
            |...|.:..|..|:|..|
  Fly   506 TIILRWWYDRGSHEIEGT 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	55/285 (19%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	57/305 (19%)
		TM helix 1	241..266	CDD:320167	4/25 (16%)
		TM helix 2	275..297	CDD:320167	3/21 (14%)
		TM helix 3	306..331	CDD:320167	8/24 (33%)
		TM helix 4	349..369	CDD:320167	7/21 (33%)
		TM helix 5	389..418	CDD:320167	6/33 (18%)
		TM helix 6	445..472	CDD:320167	9/33 (27%)
		TM helix 7	477..502	CDD:320167	6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940