DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl1 and ADGRE2

DIOPT Version :10

Sequence 1:NP_573140.1 Gene:mthl1 / 32637 FlyBaseID:FBgn0030766 Length:676 Species:Drosophila melanogaster
Sequence 2:XP_054176753.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:892 Species:Homo sapiens


Alignment Length:747 Identity:160/747 - (21%)
Similarity:245/747 - (32%) Gaps:271/747 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 PPPAAPPRPSPPPTVKLNKC------CHS--------GEY-----------------LNDGTCIA 76
            |.|.:|..|:......:::|      |.|        |.|                 ..|..|..
Human   266 PIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCED 330

  Fly    77 GSEALWLPM--VYLVQQQRFFE----------PHGAS----------------PRFLKFLPNTRP 113
            .:.:.|.|.  |:.....|||:          |..|:                |..|:.||..:.
Human   331 MTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEVPGDLETLPRLQQ 395

  Fly   114 TC----RKDQTTEIFRSRGANV------MLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQ 168
            .|    ..|...::.|....|:      ..:|.||    |.:|.||..   ||..|.   |..:|
Human   396 HCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGT----ELSLEVQKQ---VDRSVT---LRQNQ 450

  Fly   169 PINALE--------DPD---------------YAANPLVQQEPPKASLRLSKCCGKWGSYNTQLQ 210
            .:..|:        ||.               .|..||| .||.|..|                 
Human   451 AVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLV-LEPEKQML----------------- 497

  Fly   211 NCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRN-TAMLQLP- 273
               |...||    |||                     |.|...:..|...|.|..| |..|..| 
Human   498 ---LHETHQ----GLL---------------------QDGSPILLSDVISAFLSNNDTQNLSSPV 534

  Fly   274 -----HKNLSAGQYCL----EHTQR---------------EGEVKIIACQHLFSSAAGAGIHDGS 314
                 |:::...|..|    ||.|.               .....|..|.||.|.|.....:|  
Human   535 TFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYD-- 597

  Fly   315 IGGTIEQANGQNLQKAVLT----GGILVSIVFLSATLVAGFLLPAVHH---ALHWRCQIC-YVTC 371
                :::      :..|||    .|:.||::.|....:...|..|:.:   :||.:..:| ::..
Human   598 ----VQE------EDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAH 652

  Fly   372 LLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQ 436
            |||   |:||::....:     .|..:|.|:.:.:||...|:......::.|.|:....    |.
Human   653 LLF---LVAIDQTGHKV-----LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVV----NY 705

  Fly   437 EALRRYLYSL---YAWGGPLLITFVAACVDQLPETTLLRPGFGQLY-----CWFDNRNLSIFAYF 493
            .::.|::..|   ..:|.|.:...::|.         .||   .||     ||.......|:. |
Human   706 SSINRFMKKLMFPVGYGVPAVTVAISAA---------SRP---HLYGTPSRCWLQPEKGFIWG-F 757

  Fly   494 YGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSS--SEKSALGRV------CLKLVVVMGVTWI 550
            .||:..:...|:.||:.|       ||...:..||  ||.|.|...      ....:.::|.||.
Human   758 LGPVCAIFSVNLVLFLVT-------LWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWC 815

  Fly   551 ADILSWLVGGPHG---VWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGV 612
            ..||.   .||..   .:.|| :||:|||||||:|              :| .|...:..     
Human   816 LGILQ---VGPAARVMAYLFT-IINSLQGVFIFLV--------------YC-LLSQQVRE----- 856

  Fly   613 QHSSSSQGLPSMAGGTEITQNTTTTTTTTNTT 644
            |:...|:|:..:.  ||...:|.:::...:|:
Human   857 QYGKWSKGIRKLK--TESEMHTLSSSAKADTS 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl1NP_573140.1 7tmB3_Methuselah-like 326..598 CDD:410632 73/298 (24%)
TM helix 1 327..352 CDD:410632 7/28 (25%)
TM helix 2 362..384 CDD:410632 7/22 (32%)
TM helix 3 396..423 CDD:410632 5/26 (19%)
TM helix 4 441..461 CDD:410632 4/22 (18%)
TM helix 5 485..515 CDD:410632 8/29 (28%)
TM helix 6 530..557 CDD:410632 8/32 (25%)
TM helix 7 562..587 CDD:410632 12/27 (44%)
ADGRE2XP_054176753.1 EGF_CA 136..168 CDD:429571
EGF_CA 188..>220 CDD:214542
EGF_CA 232..263 CDD:429571
EGF_CA 281..312 CDD:429571 5/30 (17%)
GPS 548..598 CDD:197639 11/55 (20%)
7tmB2_EMR 602..864 CDD:320555 77/317 (24%)
TM helix 1 604..629 CDD:320555 7/24 (29%)
TM helix 2 638..660 CDD:320555 8/24 (33%)
TM helix 3 669..696 CDD:320555 5/26 (19%)
TM helix 4 713..733 CDD:320555 3/19 (16%)
TM helix 5 750..773 CDD:320555 6/23 (26%)
TM helix 6 797..822 CDD:320555 5/27 (19%)
TM helix 7 826..851 CDD:320555 13/40 (33%)
Blue background indicates that the domain is not in the aligned region.

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