DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and ADGRE2

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_011526250.1	Gene:	ADGRE2 / 30817	HGNCID:	3337	Length:	837	Species:	Homo sapiens

Alignment Length:	764	Identity:	166/764 - (21%)
Similarity:	252/764 - (32%)	Gaps:	275/764 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPPAAPPRPSPPPTVKLNKC------CHS--------GEY-----------------LNDGTCIA 76
            |.|.:|..|:......:::|      |.|        |.|                 ..|..|..
Human   197 PIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCED 261

  Fly    77 GSEALWLPM--VYLVQQQRFFE----------PHGA----------------SPRFLKFLPNTRP 113
            .:.:.|.|.  |:.....|||:          |..|                :|..|:.||..:.
Human   262 MTFSTWTPPPGVHSQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLEAPGDLETLPRLQQ 326

  Fly   114 TC----RKDQTTEIFRSRGANV------MLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQ 168
            .|    ..|...::.|....|:      ..:|.||    |.:|.||..   ||..|.   |..:|
Human   327 HCVASHLLDGLEDVLRGLSKNLSNGLLNFSYPAGT----ELSLEVQKQ---VDRSVT---LRQNQ 381

  Fly   169 PINALE--------DPD---------------YAANPLVQQEPPKASLRLSKCCGKWGSYNTQLQ 210
            .:..|:        ||.               .|..||| .||.|..|
Human   382 AVMQLDWNQAQKSGDPGPSVVGLVSIPGMGKLLAEAPLV-LEPEKQML----------------- 428

  Fly   211 NCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRN-TAMLQLP- 273
               |...||    |||                     |.|...:..|...|.|..| |..|..|
Human   429 ---LHETHQ----GLL---------------------QDGSPILLSDVISAFLSNNDTQNLSSPV 465

  Fly   274 -----HKNLSAGQYCL----EHTQR---------------EGEVKIIACQHLFSSAAGAGIHDGS 314
                 |:::...|..|    ||.|.               .....|..|.||.|.|.....:|
Human   466 TFTFSHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICRCTHLSSFAVLMAHYD-- 528

  Fly   315 IGGTIEQANGQNLQKAVLT----GGILVSIVFLSATLVAGFLLPAVHH---ALHWRCQIC-YVTC 371
                :::      :..|||    .|:.||::.|....:...|..|:.:   :||.:..:| ::..
Human   529 ----VQE------EDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAH 583

  Fly   372 LLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQ 436
            |||   |:||::....:     .|..:|.|:.:.:||...|:......::.|.|:....    |.
Human   584 LLF---LVAIDQTGHKV-----LCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVV----NY 636

  Fly   437 EALRRYLYSL---YAWGGPLLITFVAACVDQLPETTLLRPGFGQLY-----CWFDNRNLSIFAYF 493
            .::.|::..|   ..:|.|.:...::|.         .||   .||     ||.......|:. |
Human   637 SSINRFMKKLMFPVGYGVPAVTVAISAA---------SRP---HLYGTPSRCWLQPEKGFIWG-F 688

  Fly   494 YGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSS--SEKSALGRV------CLKLVVVMGVTWI 550
            .||:..:...|:.||:.|       ||...:..||  ||.|.|...      ....:.::|.||.
Human   689 LGPVCAIFSVNLVLFLVT-------LWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWC 746

  Fly   551 ADILSWLVGGPHG---VWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGV 612
            ..||.   .||..   .:.|| :||:|||||||:|              :| .|...:..
Human   747 LGILQ---VGPAARVMAYLFT-IINSLQGVFIFLV--------------YC-LLSQQVRE----- 787

  Fly   613 QHSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATHMPSNPA-EDEVPEK 660
            |:...|:|:..:.  ||...:|.:::...:|:   .||..| :|...||
Human   788 QYGKWSKGIRKLK--TESEMHTLSSSAKADTS---KPSTEAYKDGASEK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	69/276 (25%)
ADGRE2	XP_011526250.1	EGF_CA	67..117	CDD:284955
		EGF_CA	119..154	CDD:238011
		EGF_CA	163..210	CDD:284955	4/12 (33%)
		EGF_CA	212..246	CDD:284955	5/33 (15%)
		GPS	479..529	CDD:197639	11/55 (20%)
		7tm_4	533..774	CDD:304433	69/276 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810