Protein Alignment mthl1 and ADGRF1

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_722582.2
• Gene: ADGRF1 / 266977
• HGNCID: 18990
• Length: 910
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 128/604 - (21%)
• Similarity: 207/604 - (34%)
• Gaps: 192/604 - (31%)

  Fly   164 LNDSQPIN---ALEDPDYAANPLVQQ-------EPPKA-SLRLSKCCGKW-----------GSYN 206
            ||.:...|   .|.:..||::.|::.       .||.| .|..|:....|           ..|:
Human   382 LNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTALPLNFSRKFIDWKGIPVNKSQLKRGYS 446

  Fly   207 TQLQNCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDC--------------------GQPGG 251
            .|::.|  ..|....:.|.:.:      ||.|....||:.                    .|..|
Human   447 YQIKMC--PQNTSIPIRGRVLI------GSDQFQRSLPETIISMASLTLGNILPVSKNGNAQVNG 503

  Fly   252 YSIAGDWQD----------AKLDRNTAMLQLPH------KNL---SAGQYCLEHTQREGEVKIIA 297
            ..|:...|:          :|::.|   |..||      .:|   .||.:.:..||     .|:.
Human   504 PVISTVIQNYSINEVFLFFSKIESN---LSQPHCVFWDFSHLQWNDAGCHLVNETQ-----DIVT 560

  Fly   298 CQ--HLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVHHAL 360
            ||  ||.|.:.   :....:..||..     :.|.:...|:.:||        ...:|..:..||
Human   561 CQCTHLTSFSI---LMSPFVPSTIFP-----VVKWITYVGLGISI--------GSLILCLIIEAL 609

  Fly   361 HWR-------------CQICYVTCLLFGKILLAI-EELSSSLQPGSAACHTLAITMQFFFLAAFF 411
            .|:             |.:.....||...:...: ..:.:::.| |..|........||:|:.||
Human   610 FWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNP-SGVCTAAVFFTHFFYLSLFF 673

  Fly   412 WL----NTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLR 472
            |:    ..:.:.|...|....       |..:....:.| .:|.||:|:.:...|.| |..|..|
Human   674 WMLMLGILLAYRIILVFHHMA-------QHLMMAVGFCL-GYGCPLIISVITIAVTQ-PSNTYKR 729

  Fly   473 PGFGQLYCW--FDNRNLSIFAYFYGPIGLLLCAN--IALFVSTTHQLTCGLWK--------RDDV 525
            ..    .||  :.|.:..:.| |..|...::..|  :.|.|.|.      ||:        |||
Human   730 KD----VCWLNWSNGSKPLLA-FVVPALAIVAVNFVVVLLVLTK------LWRPTVGERLSRDD- 782

  Fly   526 KSSSEKSALGRVCLKLVVVMGVTW------IADI--LSWLVGGPHGVWFFTDLINALQGVFIFIV 582
            |::..:  :|:..|.|..::|:||      |.|.  |:|     |.::   .|:||.||.||.
Human   783 KATIIR--VGKSLLILTPLLGLTWGFGIGTIVDSQNLAW-----HVIF---ALLNAFQGFFIL-- 835

  Fly   583 VGCQPQVWTACRRIFC-PRLRHDITNTTNGV--------QHSSSSQGLPSMAGGTEITQN----- 633
                      |..|.. .:||..:.|..:.:        |:||.....|..:......||
Human   836 ----------CFGILLDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYA 890

  Fly   634 -TTTTTTTTNTTATHMPSN 651
             :.|..::.|...|...||
Human   891 FSHTGDSSDNIMLTQFVSN 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	65/287 (23%)
ADGRF1	NP_722582.2	SEA	154..>215	CDD:279699
		GPS	532..572	CDD:280071	13/47 (28%)
		7tm_4	582..834	CDD:304433	65/296 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900