DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and Adgrg2

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_852031.1	Gene:	Adgrg2 / 266735	RGDID:	628618	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	716	Identity:	151/716 - (21%)
Similarity:	260/716 - (36%)	Gaps:	177/716 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLQTLVSMSLA-IEEMSPPP--AAPPRP------SPPP--TV--------------KLNKCCH-- 64
            |.||.:|.:|: ::...|.|  |||..|      |.||  ||              ::.|...
  Rat   323 LPQTDLSHTLSPVQSSIPSPTTAAPSVPEKVVAISTPPGETVVNTSSVPDLEAQVSQMEKALSLG 387

  Fly    65 ------SGEYLNDGTCIAGSEALWLPMVYLVQ-QQRFFEPHGASPRFLKFLPNTRPTCRKDQTTE 122
                  :||.:|     ..|:.|..|:..|.. .||..:...|....|.|...|...........
  Rat   388 SLEPNLAGEMVN-----RVSKLLHSPLALLAPLAQRLLKVVDAIGLQLNFSSTTISLTSPSLALA 447

  Fly   123 IFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWE-------VAVVCLNDS----QPINALE-- 174
            :.|...:|.    |.|.:..:     .|::..|..|       :..:.|..|    .|.:.:|
  Rat   448 VIRVNASNF----NTTTFAAQ-----DPANLQVSLEAQAPKNSIGAITLPSSLMSNLPASEVELA 503

  Fly   175 ---DPDYAANPLVQQEPPKASLRLSKCCGKWGSY--NTQLQNCDLQPNHQAAVDGLLRLSPQLPE 234
               ..::...|.:.|:|...:|.|.       ||  ::.:.|..::...:.....|..::|...:
  Rat   504 SRVQFNFFETPALFQDPSLENLSLI-------SYVISSSVTNMTIKNLTRNVTVALKHINPSQDD 561

  Fly   235 GSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQ 299
            .:.:..:.  |..:.||   .|.|.                  |.|  |....:|..|. |..|.
  Rat   562 LTVKCVFW--DLNRNGG---RGGWS------------------SDG--CSVKEKRMNET-ICTCS 600

  Fly   300 HLFSSAAGAGIHDGSIGGTIEQANGQNL---QKAVLTG----GILVSIVFLSATLVAGFLLPAVH 357
            ||.|.            |.:...:..:|   |...||.    |..:|.:|||.|||.......:.
  Rat   601 HLTSF------------GILLDLSRTSLPPSQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIR 653

  Fly   358 HALHWR--CQICYVTCLLFGKILLAIEELSS--SLQPGSAACHTLAITMQFFFLAAFFWLNTMCF 418
            .....:  .|:| ...||...:.|    |.|  :|......|.::|:.:.:|.|.:|.|:....|
  Rat   654 RDYPSKILIQLC-AALLLLNLVFL----LDSWIALYNARGFCISVAVFLHYFLLVSFTWMGLEAF 713

  Fly   419 NIWW----TFRDFRPSSLERNQEALRRYL--YSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQ 477
            :::.    .|..:           :|:|:  :.:..||.|.::..:...:.  |:..    |.|.
  Rat   714 HMYLALVKVFNTY-----------IRKYILKFCIVGWGIPAVVVSIVLTIS--PDNY----GIGS 761

  Fly   478 L----------YCWFDNRNLSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKS 532
            .          :||. |.::..:....|...::...|:::|:....|| |.:.|:..:.:..:.|
  Rat   762 YGKFPNGTPDDFCWI-NSSVVFYITVVGYFCVIFLLNVSMFIVVLVQL-CRIKKKKQLGAQRKTS 824

  Fly   533 ALG-RVCLKLVVVMGVTWIADILSWLVGGPHGVWF--FTDLINALQGVFIFI-VVGCQPQVWTAC 593
            ... |....|..::|:||.....:|   ||..:.|  ...:.|.|||.|||| ....:..|....
  Rat   825 IQDLRSIAGLTFLLGITWGFAFFAW---GPVNLTFMYLFAIFNTLQGFFIFIFYCAAKENVRKQW 886

  Fly   594 RR-IFCPRLR----HDITNT-TNGVQHSSSSQGLPSMAGGTEITQNTTTTTT--TTNTTATHMPS 650
            || :.|.:||    .|.:.| |||::..:.:||:.|.:...:.:.|:|.:||  ..:..:.|...
  Rat   887 RRYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQSSCNSTNSTTLLVNSDCSVHASG 951

  Fly   651 N 651
            |
  Rat   952 N 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	58/276 (21%)
Adgrg2	NP_852031.1	GPS	566..608	CDD:280071	16/79 (20%)
Adgrg2	NP_852031.1	7tm_4	621..871	CDD:304433	58/276 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810