DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and Adgrf5

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_038938942.1	Gene:	Adgrf5 / 245977	RGDID:	621679	Length:	1426	Species:	Rattus norvegicus

Alignment Length:	622	Identity:	135/622 - (21%)
Similarity:	235/622 - (37%)	Gaps:	174/622 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 YLVQQQRF---FEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMV 148
            :|...:||   .|...::|.|| |.||.:                ...|:...|...:.::..:.
  Rat   902 FLQSVERFSKALELGDSTPPFL-FHPNVQ----------------MKSMVIKRGHAQMYQQKFVF 949

  Fly   149 QPSDYCVDWEVAVVCLNDSQPINALEDPDYAANPLV-----QQEPPKASLRLSKCCGKWGSYNTQ 208
            ..||...|..:....|...||.:::....:.....:     |::.|..||.::          |.
  Rat   950 TDSDLWGDVAIDECQLGSLQPDSSIVTVAFPTLKAILAQDGQRKTPSNSLVMT----------TT 1004

  Fly   209 LQNCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIA---GDWQDAKLDRNTAML 270
            :.:..::|         .|:|......  ..|.|.|.| ....:|:|   |.|.
  Rat  1005 VSHNIVKP---------FRISMTFKNN--HRSGGKPQC-VFWNFSLANNTGGWD----------- 1046

  Fly   271 QLPHKNLSAGQYC-LEHTQREGEVKIIA-CQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLT 333
                   |:|  | :|...|:...::.. |.||.|.         ||..:.:..:..:|.|.:|.
  Rat  1047 -------SSG--CTVEDDGRDNRDRVFCKCNHLTSF---------SILMSPDSPDPGSLLKILLD 1093

  Fly   334 ----GGILVSIVFLSATLVAGFLLPAVHHALHWRC----------QICYVT---CLLFGKILLAI 381
                .|:..|||.|:|.||.        .|:.|:.          .||.|.   |||...|...:
  Rat  1094 IISYIGLGFSIVSLAACLVV--------EAMVWKSVTKNRTSYMRHICIVNIALCLLIADIWFIV 1150

  Fly   382 EELSSSLQPG-----SAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRR 441
               :.::..|     ..||......:.||:|:.|||:.|:...:::........:.:..|:|:
  Rat  1151 ---AGAIHDGHYPLNETACVAATFFIHFFYLSVFFWMLTLGLMLFYRLIFILHDASKSTQKAI-- 1210

  Fly   442 YLYSLYAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWF---DNRNLSIFAYFYGPIGLLLCA 503
             .:|| .:|.||:|:.:...|.| |:...:|..    .||.   |.|.|..||.   |..:::..
  Rat  1211 -AFSL-GYGCPLIISSITVGVTQ-PQEVYMRKN----ACWLNWEDTRALLAFAI---PALIIVVV 1265

  Fly   504 NIALFVSTTHQL---TCGLWKRDDVKSSSEKSALGRVCLKLVV---VMGVTWIADILSWLVGGPH 562
            |:::.|....::   :.|     |.....|||:|.::...:.|   ::|:|| ...|:.::.|.:
  Rat  1266 NVSITVVVITKILRPSVG-----DKPGKQEKSSLFQISKSIGVLTPLLGLTW-GFGLATVIQGSN 1324

  Fly   563 GVW--FFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLPSMA 625
            .|:  .|| |:||.||:|| ::.||   :|.   :.....|.|..:.:....|||.|:    |:.
  Rat  1325 AVFHIIFT-LLNAFQGLFI-LLFGC---LWD---QKVQEALLHKFSLSRWSSQHSKST----SLG 1377

  Fly   626 GGTEI-------------------TQNTTTTTTTTNT 643
            ..|.:                   |.|.:|..||:::
  Rat  1378 SSTPVFSMSSPISRRFNNLFGKTGTYNVSTPETTSSS 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	71/282 (25%)
Adgrf5	XP_038938942.1	FR3	592..622	CDD:409353
		Ig strand E	602..608	CDD:409353
		Ig strand F	616..623	CDD:409353
		CDR3	623..632	CDD:409353
		GPS	1029..1076	CDD:396408	16/76 (21%)
		7tm_GPCRs	1090..1363	CDD:421689	77/309 (25%)
		TM helix 1	1091..1116	CDD:410628	9/32 (28%)
		TM helix 2	1131..1153	CDD:410628	7/24 (29%)
		TM helix 3	1167..1190	CDD:410628	7/22 (32%)
		TM helix 4	1210..1226	CDD:410628	6/19 (32%)
		TM helix 5	1248..1271	CDD:410628	7/25 (28%)
		TM helix 6	1295..1320	CDD:410628	5/25 (20%)
		TM helix 7	1325..1350	CDD:410628	12/29 (41%)
		SEA	181..273	CDD:396113
		IG	298..372	CDD:214652
		Ig_3	548..621	CDD:404760
		FR1	548..567	CDD:409353
		Ig strand A	548..551	CDD:409353
		Ig strand A'	555..557	CDD:409353
		Ig strand B	561..568	CDD:409353
		CDR1	568..575	CDD:409353
		Ig strand D	591..598	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810