DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and Adgrf5

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_006524187.1	Gene:	Adgrf5 / 224792	MGIID:	2182928	Length:	1406	Species:	Mus musculus

Alignment Length:	683	Identity:	147/683 - (21%)
Similarity:	253/683 - (37%)	Gaps:	200/683 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 YLNDGTCIAGSEALWLPMVYLVQQQRFFEPHGASPRFLKFLP--NTRPTCRKDQTTEIFRSRGAN 130
            ||.|.:..||.|           :|......|:....:..|.  :|.||   ...:|:.|...|.
Mouse   805 YLRDLSVSAGKE-----------EQDIRSSPGSLGAIISILDLLSTVPT---QVNSEMMRDILAT 855

  Fly   131 V-MLFPNGTLYVRERALMVQPSD-----YCVDWEVAVVCLNDSQPINALEDPDYAANPLVQQEP- 188
            : ::.....|...|:.|..|.:.     :.|:.....:.|.||       .|.:.|:|.||.:.
Mouse   856 INVILDKSALNSWEKLLQQQSNQSSQFLHSVERFSQALQLGDS-------TPPFLAHPNVQMKSM 913

  Fly   189 ------PKASLR--LSKCCGKWGSYNTQLQNC---DLQPNHQ------AAVDGLLRLSPQLPEGS 236
                  |:...:  :.|....||  :..:..|   :|||:..      ..:..:|....|....|
Mouse   914 VIKRGHPQIYQQQFIFKDSDLWG--DVAIDECQLGNLQPDSSIVTVAFPTLKAILAQDVQRKTSS 976

  Fly   237 ----------------YQTSYGLPDCGQPGG--------YSIA---GDWQDAKLDRNTAMLQLPH 274
                            ::.|....:..:.||        :|:|   |.|.
Mouse   977 NSLVMTTTVSHNIVKPFRISMTFKNNHRSGGKPQCVFWNFSLANNTGGWD--------------- 1026

  Fly   275 KNLSAGQYC-LEHTQREGEVKIIA-CQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLT---- 333
               |:|  | :|...|:...::.. |.||.|.         ||..:.:..:..:|.|.:|.
Mouse  1027 ---SSG--CSVEDDGRDNRDRVFCKCNHLTSF---------SILMSPDSPDPGSLLKILLDIISY 1077

  Fly   334 GGILVSIVFLSATLVAGFLLPAVHHALHWRC----------QICYVT---CLLFGKILLAIEELS 385
            .|:..|||.|:|.||.        .|:.|:.          .||.|.   |||...|...:   :
Mouse  1078 IGLGFSIVSLAACLVV--------EAMVWKSVTKNRTSYMRHICIVNIAFCLLIADIWFIV---A 1131

  Fly   386 SSLQPG-----SAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYS 445
            .::..|     ..||......:.||:|:.|||:.|:...:::........:.:..|:|:   .:|
Mouse  1132 GAIHDGRYPLNETACVAATFFIHFFYLSVFFWMLTLGLMLFYRLIFILHDASKSTQKAI---AFS 1193

  Fly   446 LYAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWF---DNRNLSIFAYFYGPIGLLLCANIAL 507
            | .:|.||:|:.:...|.| |:...:|..    .||.   |.|.|..||.   |..:::..|:::
Mouse  1194 L-GYGCPLIISSITVGVTQ-PQEVYMRKN----ACWLNWEDTRALLAFAI---PALIIVVVNVSI 1249

  Fly   508 FVSTTHQL---TCGLWKRDDVKSSSEKSALGRVCLKLVV---VMGVTWIADILSWLVGGPHGVW- 565
            .|....::   :.|     |.....|||:|.::...:.|   ::|:|| ...|:.::.|.:.|:
Mouse  1250 TVVVITKILRPSIG-----DKPGKQEKSSLFQISKSIGVLTPLLGLTW-GFGLATVIQGSNAVFH 1308

  Fly   566 -FFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLPSMAGGTE 629
             .|| |:||.||:|| ::.||   :|.   :.....|.|..:.:....|||.|:    |:...|.
Mouse  1309 IIFT-LLNAFQGLFI-LLFGC---LWD---QKVQEALLHKFSLSRWSSQHSKST----SIGSSTP 1361

  Fly   630 I-------------------TQNTTTTTTTTNT 643
            :                   |.|.:|..||:::
Mouse  1362 VFSMSSPISRRFNNLFGKTGTYNVSTPETTSSS 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	71/282 (25%)
Adgrf5	XP_006524187.1	IG	301..375	CDD:214652
		ig	535..608	CDD:365836
		GPS	1009..1056	CDD:366827	14/75 (19%)
		7tm_GPCRs	1070..1343	CDD:391938	77/309 (25%)
		TM helix 1	1071..1096	CDD:341315	9/32 (28%)
		TM helix 2	1111..1133	CDD:341315	7/24 (29%)
		TM helix 3	1147..1170	CDD:341315	7/22 (32%)
		TM helix 4	1190..1206	CDD:341315	6/19 (32%)
		TM helix 5	1228..1251	CDD:341315	7/25 (28%)
		TM helix 6	1275..1300	CDD:341315	5/25 (20%)
		TM helix 7	1305..1330	CDD:341315	12/29 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810