DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl1 and ADGRF5

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_005248949.1	Gene:	ADGRF5 / 221395	HGNCID:	19030	Length:	1386	Species:	Homo sapiens

Alignment Length:	453	Identity:	95/453 - (20%)
Similarity:	163/453 - (35%)	Gaps:	115/453 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 LDRNTAM---LQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANG 324
            :..||.|   :.:..||         ::...||.|.:...  |..|...|..|.| |..:|:.:|
Human   968 VSHNTTMPFRISMTFKN---------NSPSGGETKCVFWN--FRLANNTGGWDSS-GCYVEEGDG 1020

  Fly   325 QNL-------------------QKAVLTG---------GILVSIVFLSATLVAGFLLPAVHHALH 361
            .|:                   ..:.|.|         |:..||:.|:|.||.        .|:.
Human  1021 DNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAACLVV--------EAVV 1077

  Fly   362 WR-------------CQICYVTCLLFGK----ILLAIEELSSSLQPGSAACHTLAITMQFFFLAA 409
            |:             |.:.....||...    ::.||::....|  ...||......:.||:|:.
Human  1078 WKSVTKNRTSYMRHTCIVNIAASLLVANTWFIVVAAIQDNRYIL--CKTACVAATFFIHFFYLSV 1140

  Fly   410 FFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLLRPG 474
            |||:.|:...:::........:....|:|:...|    .:|.||.|:.:.....| |.....|..
Human  1141 FFWMLTLGLMLFYRLVFILHETSRSTQKAIAFCL----GYGCPLAISVITLGATQ-PREVYTRKN 1200

  Fly   475 FGQLYCWF---DNRNLSIFAYFYGPIGLLLCANIAL-FVSTTHQLTCGLWKRDDVKSSSEKSALG 535
                .||.   |.:.|..||.   |..:::..||.: .|..|..|...:   .|.....|||:|.
Human  1201 ----VCWLNWEDTKALLAFAI---PALIIVVVNITITIVVITKILRPSI---GDKPCKQEKSSLF 1255

  Fly   536 RVCLKLVV---VMGVTWIADILSWLVGGPHGVWFFTDLINALQGVFIFIVVGCQPQVWTACRRIF 597
            ::...:.|   ::|:||...:.:...|..........::|..||:|| ::.||   :|..
Human  1256 QISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFI-LLFGC---LWDL----- 1311

  Fly   598 CPRLRHDITNTTN----GVQHSSSSQGLPSMAGGTEITQNTTTTTTTTNT----TATHMPSNP 652
              :::..:.|..:    ..|||.|:    |:...|.:...::..:...|.    |.|:..|.|
Human  1312 --KVQEALLNKFSLSRWSSQHSKST----SLGSSTPVFSMSSPISRRFNNLFGKTGTYNVSTP 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	61/282 (22%)
ADGRF5	XP_005248949.1	SEA	170..259	CDD:279699
		IG_like	285..361	CDD:214653
		IGc2	285..351	CDD:197706
		IG_like	517..602	CDD:214653
		GPS	994..1036	CDD:280071	9/44 (20%)
		7tm_4	1051..1302	CDD:304433	59/275 (21%)
		7tm_1	1070..1308	CDD:278431	58/266 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810