DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and Adgrg6

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_006512741.1	Gene:	Adgrg6 / 215798	MGIID:	1916151	Length:	1258	Species:	Mus musculus

Alignment Length:	455	Identity:	106/455 - (23%)
Similarity:	184/455 - (40%)	Gaps:	88/455 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 HKNLSAGQY----CLEHTQREGEVKIIACQHLFSSAAGAGIHDG---SIGGTIEQANGQNLQKAV 331
            :||.|.|.:    |:.|:..:....|..|.|.        .|.|   .:..:..|.:|:|.:  |
Mouse   817 NKNKSFGGWNTSGCVAHSDLDAGETICLCSHF--------THFGVLMDLPRSASQIDGRNTK--V 871

  Fly   332 LTG----GILVSIVFLSATLVAGFLLPAVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGS 392
            ||.    |..:|.:|.:|||:.......:......:..:...:.|||..::..::...:|.  |.
Mouse   872 LTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSSALLFLNLIFLLDGWVTSF--GV 934

  Fly   393 AA-CHTLAITMQFFFLAAFFWLNTMCFNIW----WTFRDFRPSSLERNQEALRRYL--YSLYAWG 450
            |. |..:|..:.||.||.|.|:.....:::    ..|..:           :.||:  :.:..||
Mouse   935 AGLCTAVAALLHFFLLATFTWMGLEAIHMYIALVKVFNTY-----------IHRYILKFCIIGWG 988

  Fly   451 GPLLITFVAACVDQLPETTLLRPGFGQ----LYCWFDNRNLSIFAYFY----GPIGLLLCANIAL 507
            .|.|:..: ..|.:.......:..:|:    .:||..:.     ..||    |..|::...|:|:
Mouse   989 LPALVVSI-ILVSRRQNEVYGKESYGKDQDDEFCWIQDP-----VVFYVSCAGYFGVMFFLNVAM 1047

  Fly   508 FVSTTHQLTCGL-WKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGV--WFFTD 569
            |:....|: ||. .||.:.....|.....|..:.|..::|:||.....:|   ||..:  .:...
Mouse  1048 FIVVMVQI-CGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAW---GPLNIPFMYLFS 1108

  Fly   570 LINALQGVFIFIV-----VGCQPQVWTACRRIFCPRLR----HDITNT-TNGVQHSSSSQG--LP 622
            :.|:|||:||||.     ...|.| |.  |.:.|.|.|    .|.:.| ||.::.||.:.|  |.
Mouse  1109 IFNSLQGLFIFIFHCAMKENVQKQ-WR--RHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLS 1170

  Fly   623 SMAGG---TEITQNTTTTTTTTNTTATHMPSNPAEDEVP-------EKAPIAPVAPIV-KMETIC 676
            |.:.|   |.:|..:.:::||.....:|..|...:..:.       |:..|.||..:: |::..|
Mouse  1171 SSSIGSNSTYLTSKSKSSSTTYFKRNSHSDSTSTDKSLSKLTHAGGEQTSIIPVHQVIDKVKGYC 1235

Fly 677 676
Mouse 1236 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	59/271 (22%)
Adgrg6	XP_006512741.1	CUB	48..156	CDD:238001
		LamG	188..347	CDD:389952
		HRM	543..588	CDD:382965
		GPS	809..854	CDD:366827	11/44 (25%)
		7tm_GPCRs	869..1137	CDD:391938	67/295 (23%)
		TM helix 1	871..896	CDD:341315	9/24 (38%)
		TM helix 2	906..928	CDD:341315	3/21 (14%)
		TM helix 3	939..966	CDD:341315	7/26 (27%)
		TM helix 4	981..997	CDD:341315	4/16 (25%)
		TM helix 5	1026..1049	CDD:341315	6/27 (22%)
		TM helix 6	1072..1097	CDD:341315	6/27 (22%)
		TM helix 7	1101..1126	CDD:341315	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810