DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and lat-1

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001366731.1	Gene:	lat-1 / 174419	WormBaseID:	WBGene00002251	Length:	1014	Species:	Caenorhabditis elegans

Alignment Length:	768	Identity:	153/768 - (19%)
Similarity:	255/768 - (33%)	Gaps:	240/768 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 AAPPRPSPPPTVKLNKCCHSGEYLNDGTCIAGSEALWL--------------------------- 83
            ::.|.|......:|..|...|::|.:....||.|:.|:
Worm   203 SSAPCPEGSSGKQLWACTEEGQWLTEFPNSAGCESNWISSRNSVLSGVISSEDVSGLPEFLRNLG 267

  Fly    84 -----PMVYLVQQQRFFEPHGASPRFLKFLPNT-------------------------------- 111
                 |||           .|..|:.|..|..|
Worm   268 SETRRPMV-----------GGDLPKVLHLLEKTVNVIAEESWAYQHLPLSNKGAVEVMNYMLRNQ 321

  Fly   112 ------RPTCRKDQTTEIFRSRGANVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPI 170
                  ..|.||:..:....:....::....|.:...|..::|||:   :..|::......|||
Worm   322 EIWGSWDVTKRKEFASRFILAAEKAMVASAKGMMTSAESNVIVQPA---ITVEISHKIKMSSQP- 382

  Fly   171 NALEDPDYAANPLVQQEPPKASLRLSKCCGKWGSYNTQLQNCDLQPNHQAAVDGLLRLSPQLPEG 235
                 .||...       |.|:|        |..     ||.|   |.....|.:|:::....:.
Worm   383 -----TDYILF-------PSAAL--------WNG-----QNVD---NVNIPRDAILKINKDETQV 419

  Fly   236 SYQTSYGLPDCGQPG------------------------GYSIAGDWQDAKLDRNTAMLQLP--H 274
            .:.:...|.....|.                        |.|:..:.::.:::..|..:::.  |
Worm   420 FFSSFDNLGAQMTPSDVTVAIAGTDQTEVRKRRVVSRIVGASLIENGKERRVENLTQPVRITFYH 484

  Fly   275 KNLS----AGQYCLEHTQREGEVKIIACQ--------------HLFSSAAGAGIHDGSIGGTIEQ 321
            |..|    :...|:.....|.:.|...|:              ||...|....:.    |..:.:
Worm   485 KESSVRHLSNPTCVWWNHHELKWKPSGCKLSYHNKTMTSCDCTHLTHFAVLMDVR----GHDLNE 545

  Fly   322 ANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPA-------VHHALHWRCQICYVTCLLFGKILL 379
            .: |.|...:...|.::||:.|..|..|..:...       :|..|.....|..:|      .|.
Worm   546 ID-QTLLTLLTYVGCIISIICLLLTFFAYLIFSRNGGDRVFIHENLCLSLAIAEIT------FLA 603

  Fly   380 AIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLY 444
            .|.....|||     |..:|:.:.:.||:|..|:....::|.....:..||.       .||:.|
Worm   604 GITRTEDSLQ-----CGIIAVALMYMFLSALTWMLLEGYHIHRMLTEVFPSD-------PRRFTY 656

  Fly   445 SLYAWGGPLLITFVAACVDQLPETTLLRPGFGQL-YCWFDNRNLSIFAYFYGPIGLLLCANIALF 508
            .|..:..|.:||.||...:.        .|||.. :||...:|..|: :|.||...:.|||..:.
Worm   657 LLVGYIPPAIITLVAYLYNS--------DGFGTPDHCWLSTQNNFIW-FFAGPACFIFCANSLVL 712

  Fly   509 VS---TTHQLTCG--LWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHGV--WF 566
            |.   |.:|.|.|  |..|.||.|........:..|.|..::|||||.. |.|:......|  :.
Worm   713 VKTLCTVYQHTSGGYLPCRHDVDSGRSIRNWVKGSLALASLLGVTWIFG-LFWVEDSRSIVMAYV 776

  Fly   567 FTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDI------------TNTT-----NGVQH 614
            || :.|:|||:|||:.           ..:|..::|.|:            :|::     :.||.
Worm   777 FT-ISNSLQGLFIFLF-----------HVVFAEKMRKDVGHWMYRRGCGGSSNSSPNHKRHNVQR 829

  Fly   615 SSSSQGLPSMAGGTEITQNT-----TTTTTTTNTTATHMPSNPAEDEVPEKAP 662
            ...|.|:.| :.|::...||     |.:.||.......:.::|.:..|.::.|
Worm   830 DLMSPGVNS-STGSDFLYNTNDKYLTNSDTTNRLVYNGIMNHPNQMSVYQQHP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	72/264 (27%)
lat-1	NP_001366731.1	Gal_Lectin	51..133	CDD:396628
		HormR	180..244	CDD:214468	10/40 (25%)
		GAIN	258..462	CDD:406802	35/246 (14%)
		GPS	493..541	CDD:197639	7/51 (14%)
		7tmB2_latrophilin-like_invertebrate	548..808	CDD:320556	80/299 (27%)
		TM helix 1	551..575	CDD:320556	6/23 (26%)
		TM helix 2	584..605	CDD:320556	5/26 (19%)
		TM helix 3	615..637	CDD:320556	5/21 (24%)
		TM helix 4	655..671	CDD:320556	5/15 (33%)
		TM helix 5	690..713	CDD:320556	8/23 (35%)
		TM helix 6	744..766	CDD:320556	9/22 (41%)
		TM helix 7	771..796	CDD:320556	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910