Protein Alignment mthl1 and ADGRF3

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001138640.1
• Gene: ADGRF3 / 165082
• HGNCID: 18989
• Length: 1079
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 120/552 - (21%)
• Similarity: 192/552 - (34%)
• Gaps: 183/552 - (33%)

  Fly   150 PSDYCVDWEVAVVCLNDSQPINALEDPDYAANPLVQQ--EPPKASLRLSKCCGKWGSYNTQLQNC 212
            |:||.:.:..       ..|:.| :.|.::..|||:.  |....||.|.|           |.:.
Human   620 PADYSISFPT-------RPPLQA-QIPRHSLAPLVRNGTEISITSLVLRK-----------LDHL 665

  Fly   213 DLQPNHQAAVDGLLRLSPQL-------------PEGSYQTSYGLPDCGQP-------------GG 251
             |..|:...:...|..:|.|             .:|.....:|..| |.|             ||
Human   666 -LPSNYGQGLGDSLYATPGLVLVISIMAGDRAFSQGEVIMDFGNTD-GSPHCVFWDHSLFQGRGG 728

  Fly   252 YSIAGDWQDAKLDRNTAMLQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIG 316
            :|..|             .|....:.|....||             ||||.:.:.....|
Human   729 WSKEG-------------CQAQVASASPTAQCL-------------CQHLTAFSVLMSPH----- 762

  Fly   317 GTIEQANGQNLQKAVLTGGILVSIVFLSATLVAGFLLPAVHHALHWR------------------ 363
             |:.:      :.|:    .|::.|.|.|:::|..:...|:. |.||
Human   763 -TVPE------EPAL----ALLTQVGLGASILALLVCLGVYW-LVWRVVVRNKISYFRHAALLNM 815

  Fly   364 --CQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWL----NTMCFNIWW 422
              |.:...||.|....|        |..|.|..|...|....|.:||.|||:    ..:...:.:
Human   816 VFCLLAADTCFLGAPFL--------SPGPRSPLCLAAAFLCHFLYLATFFWMLAQALVLAHQLLF 872

  Fly   423 TFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACV---------DQLPETTLLRPGFGQL 478
            .|          :|.|..|.|        ||::.....|.         ..||:...||.|
Human   873 VF----------HQLAKHRVL--------PLMVLLGYLCPLGLAGVTLGLYLPQGQYLREG---- 915

  Fly   479 YCWFDNRNLSIFAYFYGPIGLLLCAN-IALFVSTTHQLTCGLWKRDDVKSSSEKSALG--RVCLK 540
            .||.|.:..:::. |.||:..::..| :.|.::....|...|  .:...:...::.||  :..|.
Human   916 ECWLDGKGGALYT-FVGPVLAIIGVNGLVLAMAMLKLLRPSL--SEGPPAEKRQALLGVIKALLI 977

  Fly   541 LVVVMGVTW---IADILSWLVGGPHGVWFFTDLINALQGVFIFIVVGC--QPQVWTACRRIFCPR 600
            |..:.|:||   :|.:|..:...||  :.|| ::|.|||||| ::.||  ..::..|.|:.||
Human   978 LTPIFGLTWGLGLATLLEEVSTVPH--YIFT-ILNTLQGVFI-LLFGCLMDRKIQEALRKRFC-- 1036

  Fly   601 LRHDITNTTNGV----------QHSSSSQGLP 622
             |....::|..:          ...|.|:|:|
Human  1037 -RAQAPSSTISLVSCCLQILSCASKSMSEGIP 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	67/288 (23%)
ADGRF3	NP_001138640.1	HRM	431..477	CDD:280888
		GPS	713..758	CDD:280071	13/70 (19%)
		7tm_4	770..1016	CDD:304433	66/286 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810