DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl1 and Adgrg1

DIOPT Version :9

Sequence 1:NP_001285340.1 Gene:mthl1 / 32637 FlyBaseID:FBgn0030766 Length:676 Species:Drosophila melanogaster
Sequence 2:XP_006530743.1 Gene:Adgrg1 / 14766 MGIID:1340051 Length:718 Species:Mus musculus


Alignment Length:396 Identity:76/396 - (19%)
Similarity:139/396 - (35%) Gaps:102/396 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 QREGEVKIIACQHLFSSAAGAGIHD--GSIGGTIEQANGQNLQKAVLTGGILVSIVFLSATLVAG 350
            |.:.:.|.:..|.:|      .:.|  .|..|:...|..:.:.:...|..:...:.:.:..:|:.
Mouse   365 QHQPQPKNVTLQCVF------WVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLMVSS 423

  Fly   351 FLLPAVHHALHWRCQICYVTC-------------------------------LLFGKILLAIEEL 384
            ..:.|.|.  |:...:.||.|                               ||....||.:..|
Mouse   424 TEVEATHK--HYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLSAVFLLDVSFL 486

  Fly   385 SS---SLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIW----WTFRDFRPSSLERNQEALRRY 442
            .|   :|....|||.|.|:.:.|..||...|:....:|::    ..|..:.|..|.:        
Mouse   487 LSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLK-------- 543

  Fly   443 LYSLYAWGGPLLITFVAACVD------------QLPETTLLRPGFGQLYCWFDNRNLSIFAYF-- 493
             .|:..||.|:.:..:.|.||            :.||    |..:..: ||..:   |:.:|.  
Mouse   544 -LSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPE----RVTYPSM-CWIRD---SLVSYVTN 599

  Fly   494 YGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLV 558
            .|...|:...|:|:..:...|:.       .::..|:........|.|.:|:|:.|.....|:..
Mouse   600 LGLFSLVFLFNLAMLATMVVQIL-------RLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSFAS 657

  Fly   559 GG-PHGVWFFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSSQGLP 622
            |. ...:.:...:|.:.||..||:      ..|:         :|.......:.::::|.|..||
Mouse   658 GTFQLVILYLFSIITSFQGFLIFL------WYWS---------MRFQAQGGPSPLKNNSDSAKLP 707

  Fly   623 SMAGGT 628
            ..:|.|
Mouse   708 ISSGST 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl1NP_001285340.1 7tm_4 329..579 CDD:304433 58/302 (19%)
Adgrg1XP_006530743.1 PLL 60..193 CDD:376013
GAIN_A 204..251 CDD:376045
GPS 376..419 CDD:366827 7/48 (15%)
7tm_GPCRs 431..698 CDD:391938 58/307 (19%)
TM helix 1 433..458 CDD:341315 3/24 (13%)
TM helix 2 468..490 CDD:341315 6/21 (29%)
TM helix 3 501..528 CDD:341315 7/26 (27%)
TM helix 4 541..561 CDD:341315 5/28 (18%)
TM helix 5 592..621 CDD:341315 6/28 (21%)
TM helix 6 629..656 CDD:341315 6/26 (23%)
TM helix 7 662..687 CDD:341315 6/39 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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