DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and ADGRG4

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_722576.3	Gene:	ADGRG4 / 139378	HGNCID:	18992	Length:	3080	Species:	Homo sapiens

Alignment Length:	410	Identity:	94/410 - (22%)
Similarity:	159/410 - (38%)	Gaps:	91/410 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 IIACQHLFSSAAGAGIHDGSI----GGTIEQANGQNLQKAVLTG-GILVSIVFLSATLVAGFLLP 354
            |..|.||        .|.|.:    ..|::..|.|.|.....|| ||  |.:||...:|......
Human  2715 ICQCDHL--------THFGVLMDLSRSTVDSVNEQILALITYTGCGI--SSIFLGVAVVTYIAFH 2769

  Fly   355 AVHHALHWRCQICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFN 419
            .:......:..|...|.||...::..|....||.|. ...|.|.|:.:.:|.|.:|.|:.....:
Human  2770 KLRKDYPAKILINLCTALLMLNLVFLINSWLSSFQK-VGVCITAAVALHYFLLVSFTWMGLEAVH 2833

  Fly   420 IWW----TFRDFRPSSLERNQEALRRYLYSLYAWGGPLLITFVAACVDQ-----LPETTLLRPGF 475
            ::.    .|..:.|:.:.:         :.|..||.|.::..:...|.:     |..||   |
Human  2834 MYLALVKVFNIYIPNYILK---------FCLVGWGIPAIMVAITVSVKKDLYGTLSPTT---P-- 2884

  Fly   476 GQLYCWFDNRN---LSIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRV 537
               :||..:.:   :|:.|||.    |:...|:::|.:...||       :.|||..:|:....:
Human  2885 ---FCWIKDDSIFYISVVAYFC----LIFLMNLSMFCTVLVQL-------NSVKSQIQKTRRKMI 2935

  Fly   538 ------CLKLVVVMGVTWIADILSWLVGGPHGVWF--FTDLINALQGVFIFIV-------VGCQP 587
                  .:.|..::|:||.....:|   ||...:|  ...:.|.|||.|||:.       |..|.
Human  2936 LHDLKGTMSLTFLLGLTWGFAFFAW---GPMRNFFLYLFAIFNTLQGFFIFVFHCVMKESVREQW 2997

  Fly   588 QVWTACRRIFCPRLRHDITNTTNG-----VQHSSSSQGLPSMAGGTEITQN-TTTTTTTTNTTAT 646
            |:     .:.|..||.|  |:::|     ::.....:||..:.....:|.: .:|.|::|..:..
Human  2998 QI-----HLCCGWLRLD--NSSDGSSRCQIKVGYKQEGLKKIFEHKLLTPSLKSTATSSTFKSLG 3055

  Fly   647 HMPSNPAEDEVP----EKAP 662
            .....|:|...|    :|.|
Human  3056 SAQGTPSEISFPNDDFDKDP 3075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	61/270 (23%)
ADGRG4	NP_722576.3	LamG	28..210	CDD:304605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	946..965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1348
		CytochromB561_N	<1668..>1909	CDD:286826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2109..2141
		GPS	2684..2727	CDD:280071	6/19 (32%)
		7tm_2	2743..2982	CDD:278432	62/272 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3051..3080		5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810