Protein Alignment mthl1 and mthl11

DIOPT Version :10

• Sequence 1: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 113/525 - (21%)
• Similarity: 191/525 - (36%)
• Gaps: 134/525 - (25%)

  Fly   203 GSYNTQLQNCDLQPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNT 267
            |..:..:.|||.....|      ||.|.:|..|||:....:......|.|       |.::|.:.
  Fly    17 GVRSRDIPNCDFFDTVQ------LRESEKLCNGSYRYEDVVIPAKLTGKY-------DYEIDYDG 68

  Fly   268 AMLQLP-------------------HKNLSAG-------------QYCLEHTQREGEV------- 293
            ..:.:|                   ||.|.||             :|.|:.||..|.|
  Fly    69 DRVSVPKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYTLDITQLNGSVIKKHVLN 133

  Fly   294 -------KIIACQHLFSSAAGAGIHD-------GSIGGTIEQ---------------ANGQN--- 326
                   ..:.|:..:|..|....:|       ||:....:|               :.|:|
  Fly   134 DMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYSL 198

  Fly   327 ---------------------LQKAVLTGG---ILVSIVFLSATLVAGFLLPAVHHALHWRCQIC 367
                                 ::|:.|:..   :..|.||.....:|.:|......:||.:|...
  Fly   199 IVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCCNL 263

  Fly   368 YVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSL 432
            |..||.. ..||.:..|....:..:..|:.......|..:|.|.||:.:.|::|..|...:....
  Fly   264 YFICLAI-TFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQVF 327

  Fly   433 ERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTL---LRPGFGQLYCWFDNRNLSIFAYFY 494
            .:|:.: ..:.|::..|....|:|.:...|||..||.|   ..|..|...||......|...|||
  Fly   328 YKNKRS-SFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVGVFSCWIFTNGWSATFYFY 391

  Fly   495 GPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALG------RVCLKLVVVMGVTWIADI 553
            .|:.:|:..|.|.|..||..:.....:...|.::||...|.      |:..:|.::||.:|..:|
  Fly   392 APLAILIILNCASFFLTTRYIYVENKQNQKVLNNSEPQKLSRNHANYRIYFRLFIIMGGSWFLEI 456

  Fly   554 LSWLVGGPHGVW----FFTDLINALQGVFIFIVVGCQPQVWTACRRIFCPRLRH------DITNT 608
            ::::. ....:|    ...|.||..||:.||:...|..:::...|:    |:::      ::|||
  Fly   457 IAFIC-EMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRK----RIQNRNITSLELTNT 516

  Fly   609 TNGVQ 613
            :..|:
  Fly   517 SRPVE 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	72/311 (23%)
		TM helix 1	327..352	CDD:410632	6/27 (22%)
		TM helix 2	362..384	CDD:410632	6/21 (29%)
		TM helix 3	396..423	CDD:410632	7/26 (27%)
		TM helix 4	441..461	CDD:410632	4/19 (21%)
		TM helix 5	485..515	CDD:410632	11/29 (38%)
		TM helix 6	530..557	CDD:410632	8/32 (25%)
		TM helix 7	562..587	CDD:410632	9/28 (32%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	35/190 (18%)
		7tmB3_Methuselah-like	236..504	CDD:410632	69/274 (25%)
		TM helix 2	258..280	CDD:410632	6/22 (27%)
		TM helix 3	291..318	CDD:410632	7/26 (27%)
		TM helix 4	335..355	CDD:410632	4/19 (21%)
		TM helix 5	383..412	CDD:410632	11/28 (39%)
		TM helix 6	433..460	CDD:410632	6/26 (23%)
		TM helix 7	468..493	CDD:410632	8/24 (33%)