DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and adgrf3a

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_021322955.1	Gene:	adgrf3a / 101886922	ZFINID:	ZDB-GENE-131121-607	Length:	949	Species:	Danio rerio

Alignment Length:	601	Identity:	127/601 - (21%)
Similarity:	201/601 - (33%)	Gaps:	168/601 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 KDQTTEIFR----SRGANVMLFPNGTLYVRERALMVQPSDYCV----DWEVAVVCLNDSQPINAL 173
            ||...::|:    |.......|||....|....:|   :|...    .|...|:....|...|.|
Zfish   414 KDNADQLFQRINDSTTLRTFTFPNIETSVNIFGVM---NDVSTRQQNQWNDTVMSKLVSSASNLL 475

  Fly   174 EDPDYAANP-----------------------LVQQEPPKASLRLSKCCGKWG------SYNTQL 209
            .||....||                       |:...|..:|......|....      ::|..:
Zfish   476 NDPSGWQNPENKSIFISVEYLKTIERMMNNSNLISNTPYISSNAQMALCNHTSPADICKTFNASV 540

  Fly   210 QNCDLQPNHQAAVDGLLRLSPQLP--EGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNTAMLQL 272
            :|.|    :...|.|...|...||  ||:                           |.||.:|.:
Zfish   541 RNSD----NSVVVFGFRNLYQILPKAEGN---------------------------DSNTTILSV 574

  Fly   273 PHKNL------------SAGQ-------YCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGT 318
            ...|.            ||.|       ||:...:...|.....|:..........|.|.:...|
Zfish   575 TPVNANNTNRSITLEFDSAKQRLPNHMIYCVYWDENLNEWSSDGCRWAGVDNPTLCICDHNSAFT 639

  Fly   319 IEQA-NGQNL--QKAVLTGGILVSIVFLSATLVAGFLL-PAV--------HHALHWRCQICYVTC 371
            |..: |.:.|  ...:...|:.:||:.|.|.|:...|: .||        .|...:...:    |
Zfish   640 ILMSKNAETLPYMDELTYAGLGISILSLLACLIIKVLVWDAVVKSPISNFRHVALFNISL----C 700

  Fly   372 LLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFWLNTMCF----NIWWTFRDFRPSSL 432
            ||....:........|:.|.  .|..|.:...|||||.|||:..:.|    .:.:.|
Zfish   701 LLLAHCMFLTTSKPESIPPN--WCSILTLIKHFFFLAVFFWMLCLSFVLLHQMIYVF-------- 755

  Fly   433 ERNQEALRRYLYSLYAWGGPLLITFVAACVDQLPETTLL---RPGFGQLY----CWFDNRNL--- 487
                :.||:.::.      .|.||...||.......|.:   ....|:.|    ||...:..
Zfish   756 ----DRLRKKVFL------GLSITVGYACPIIAVAVTYISFNNGAEGEYYSKSTCWLTYKGTLKG 810

  Fly   488 SIFAYFYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVV----VMGVT 548
            ||||:.. |||.::..|  ||......:........:.|:..||. :.:..:|.:|    |:|::
Zfish   811 SIFAFII-PIGAIVFVN--LFTLAVVIMKIATPSISEAKARDEKD-VAKSMIKTIVFLSPVLGLS 871

  Fly   549 WIADILSWLVGG------PHGV---WFFTDLINALQGVFIFIVVGC--QPQVWTACRRIFCPRLR 602
            |   :|.:.|.|      |...   :.|| :.|:|||:|| ::..|  :.:|..|..:.|  :::
Zfish   872 W---VLGFFVLGLDLTVKPWAALVNYSFT-IFNSLQGLFI-LLTNCVGEKKVRDALLKRF--KIK 929

  Fly   603 HDITNTTNGVQHSSSS 618
            ..:.:.|.....:.||
Zfish   930 QSVHSKTESSSKAQSS 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	67/285 (24%)
adgrf3a	XP_021322955.1	GPS	604..641	CDD:307782	6/36 (17%)
		7tm_GPCRs	649..926	CDD:333717	73/309 (24%)
		TM helix 1	652..676	CDD:320095	6/23 (26%)
		TM helix 2	691..712	CDD:320095	4/24 (17%)
		TM helix 3	723..745	CDD:320095	9/21 (43%)
		TM helix 4	766..782	CDD:320095	5/15 (33%)
		TM helix 5	805..831	CDD:320095	10/28 (36%)
		TM helix 6	855..881	CDD:320095	7/28 (25%)
		TM helix 7	890..915	CDD:320095	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810