Protein Alignment mthl1 and adgrf3a

DIOPT Version :10

• Sequence 1: NP_573140.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: XP_021322955.3
• Gene: adgrf3a / 101886922
• ZFINID: ZDB-GENE-131121-607
• Length: 997
• Species: Danio rerio
• Alignment Length: 585
• Identity: 128/585 - (21%)
• Similarity: 206/585 - (35%)
• Gaps: 136/585 - (23%)

  Fly   117 KDQTTEIFR----SRGANVMLFPNGTLYVRERALMVQPSDYCV----DWEVAVVCLNDSQPINAL 173
            ||...::|:    |.......|||....|....:|   :|...    .|...|:....|...|.|
Zfish   462 KDNADQLFQRINDSTTLRTFTFPNIETSVNIFGVM---NDVSTRQQNQWNDTVMSKLVSSASNLL 523

  Fly   174 EDPDYAANP-----------------------LVQQEPPKASLRLSKCCGKWG------SYNTQL 209
            .||....||                       |:...|..:|......|....      ::|..:
Zfish   524 NDPSGWQNPENKSIFISVEYLKTIERMMNNSNLISNTPYISSNAQMALCNHTSPADICKTFNASV 588

  Fly   210 QNCDLQPNHQAAVDGLLRLSPQLP--EGSYQTSYGL---PDCGQPGGYSIAGDWQDAKLDRNTAM 269
            :|.|    :...|.|...|...||  ||:...:..|   |........||.       |:.::|.
Zfish   589 RNSD----NSVVVFGFRNLYQILPKAEGNDSNTTILSVTPVNANNTNRSIT-------LEFDSAK 642

  Fly   270 LQLPHKNLSAGQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQA-NGQNL--QKAV 331
            .:||:..:    ||:...:...|.....|:..........|.|.:...||..: |.:.|  ...:
Zfish   643 QRLPNHMI----YCVYWDENLNEWSSDGCRWAGVDNPTLCICDHNSAFTILMSKNAETLPYMDEL 703

  Fly   332 LTGGILVSIVFLSATLVAGFLL-PAV--------HHALHWRCQICYVTCLLFGKILLAIEELSSS 387
            ...|:.:||:.|.|.|:...|: .||        .|...:...:    |||....:........|
Zfish   704 TYAGLGISILSLLACLIIKVLVWDAVVKSPISNFRHVALFNISL----CLLLAHCMFLTTSKPES 764

  Fly   388 LQPGSAACHTLAITMQFFFLAAFFWLNTMCF----NIWWTFRDFRPSSLERNQEALRRYLYSLYA 448
            :.|.  .|..|.:...|||||.|||:..:.|    .:.:.|            :.||:.::.
Zfish   765 IPPN--WCSILTLIKHFFFLAVFFWMLCLSFVLLHQMIYVF------------DRLRKKVFL--- 812

  Fly   449 WGGPLLITFVAACVDQLPETTLL---RPGFGQLY----CWFDNRNL---SIFAYFYGPIGLLLCA 503
               .|.||...||.......|.:   ....|:.|    ||...:..   ||||:.. |||.::..
Zfish   813 ---GLSITVGYACPIIAVAVTYISFNNGAEGEYYSKSTCWLTYKGTLKGSIFAFII-PIGAIVFV 873

  Fly   504 NIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRVCLKLVV----VMGVTWIADILSWLVGG---- 560
            |  ||......:........:.|:..||. :.:..:|.:|    |:|::|   :|.:.|.|
Zfish   874 N--LFTLAVVIMKIATPSISEAKARDEKD-VAKSMIKTIVFLSPVLGLSW---VLGFFVLGLDLT 932

  Fly   561 --PHGV---WFFTDLINALQGVFIFIV--VGCQPQVWTACRRIFCPRLRHDITNTTNGVQHSSSS 618
              |...   :.|| :.|:|||:||.:.  || :.:|..|..:.|  :::..:.:.|.....:.||
Zfish   933 VKPWAALVNYSFT-IFNSLQGLFILLTNCVG-EKKVRDALLKRF--KIKQSVHSKTESSSKAQSS 993

  Fly   619  618
            Zfish   994  993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_573140.1	7tmB3_Methuselah-like	326..598	CDD:410632	74/311 (24%)
		TM helix 1	327..352	CDD:410632	7/26 (27%)
		TM helix 2	362..384	CDD:410632	3/21 (14%)
		TM helix 3	396..423	CDD:410632	10/30 (33%)
		TM helix 4	441..461	CDD:410632	3/19 (16%)
		TM helix 5	485..515	CDD:410632	10/32 (31%)
		TM helix 6	530..557	CDD:410632	8/30 (27%)
		TM helix 7	562..587	CDD:410632	10/29 (34%)
adgrf3a	XP_021322955.3	None