DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl1 and adgre5b.2

DIOPT Version :9

Sequence 1:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	XP_005160278.1	Gene:	adgre5b.2 / 101882660	ZFINID:	ZDB-GENE-121214-277	Length:	693	Species:	Danio rerio

Alignment Length:	701	Identity:	142/701 - (20%)
Similarity:	242/701 - (34%)	Gaps:	211/701 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRSSRAASSNQFIRPCGLLTTVILLQTLVSMSLAIEEMSPPPAAPPRPSPPPTVKLNKCC----H 64
            :::|...|.|.|:.|.|...     ||    .:..::....|.....|.     |||:..    .
Zfish   107 TQTSETTSQNAFVSPKGAAE-----QT----EIECDQFKSKPDEDHTPE-----KLNQMMSLLKD 157

  Fly    65 SGEYLNDGTCIAGSEALWLPMVYLVQQQRFFEPHGASPRFLKFLPNTRPTCRKDQTTEIFRSRGA 129
            |.|.|||            |:          |.|..:...|:.|.|:    ..|...|...:.|.
Zfish   158 SCESLND------------PV----------EKHFNAEELLENLCNS----TDDLLLEGKVADGE 196

  Fly   130 NVMLFPNGTLYVRERALMVQPSDYCVDWEVAVVCLNDSQPINALEDPD-YAANPLVQ-QEPPKAS 192
            |:.:|.:   .|.....::.|.            |.|  |:..:|..: ||...|.: |.||..|
Zfish   197 NLSVFLD---MVENSMRLIGPQ------------LKD--PVTKMETQNTYAEVALTRNQTPPSGS 244

  Fly   193 LRLSKCCG----KWG----------------SYNTQLQNCDLQPNHQAA----VDGLLRLSPQLP 233
            :.||....    .|.                ||.....:.||  :|:.:    .|...||.....
Zfish   245 VTLSTDSALFSTSWETVVGKAYSGFAFVALFSYKDMNSSSDL--SHKTSRTLQEDSRKRLHVDEK 307

  Fly   234 EGSYQTSYGLPDC--GQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSA----------------- 279
            :.:||.:..:...  ..|          |.|...:..||...|:...|
Zfish   308 KITYQLNSKVVTAVVSNP----------DTKKLSDLMMLTFTHEEERAESGGVAYTCVYWNESEK 362

  Fly   280 ---GQYCLE------HTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNLQKAVLTGG 335
               |:.|::      ||       :....||.|.|....::  .:..|.              ..
Zfish   363 VWSGRGCVKEWSNSTHT-------VCHWSHLSSFAVLMALY--PVQDTF--------------AS 404

  Fly   336 ILVSIVFLSATLVAGFL----------LPAVHHALHWRCQIC-YVTCLLFGKILLAIEELSSSLQ 389
            :|::.|.|..:|:..||          :....:::|....:| ::..|:|   |..|....:.:
Zfish   405 VLITRVGLVLSLLCLFLCILTFRFCRSIQGTRNSIHLHLSVCLFIADLVF---LCGISSTHNQV- 465

  Fly   390 PGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSLERNQEALRRYLYSLYAWGGPLL 454
                ||..:|..:.||||:||.|:......:      :|...|..:......|||:: .:|.||:
Zfish   466 ----ACAIVAGLLHFFFLSAFCWMLLEGVQL------YRMVVLVFHTTLKHLYLYAV-GYGVPLV 519

  Fly   455 ITFVAACVDQLPETTLLRPGFG-QLYCWFDNRNLSIFAY----FYGPIGLLLCANIALFVSTTHQ 514
            |..::|..  .|:      |:| ..:||     ||:..|    |:.|:.:::..||.:|:.|..:
Zfish   520 IVSISAIT--FPK------GYGTNKHCW-----LSLEGYLILSFFAPVCIIVILNIIVFIITVWK 571

  Fly   515 LTCGLWKRDDVKSSSEK------SALGRVCLKLVVVMGVTWIADILSWLVGGPHGVWFFTDLINA 573
            |.......:...|...|      :|:.::|     |:|.:|:.....:...|...:.:...::|:
Zfish   572 LALKFSSLNPDLSKLHKIRSFLATAVAQLC-----VLGGSWVFGFFLFQKNGTEVMLYLFIILNS 631

  Fly   574 LQGVFIFIVVGC--QPQVWTACRRIF---CPRLRHDITNTTNGVQHSSSSQ 619
            |||..||| :.|  ..||......:|   ||..:....:.:....|||..:
Zfish   632 LQGALIFI-MHCLLSKQVRVEYHSLFVRMCPYKKKGDYSVSTEPSHSSQKR 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	59/271 (22%)
adgre5b.2	XP_005160278.1	GPS	353..398	CDD:197639	8/53 (15%)
adgre5b.2	XP_005160278.1	7tm_4	406..637	CDD:304433	59/263 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910