Protein Alignment mthl1 and ADGRG2

DIOPT Version :9

• Sequence 1: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Sequence 2: NP_001073327.1
• Gene: ADGRG2 / 10149
• HGNCID: 4516
• Length: 1017
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 153/739 - (20%)
• Similarity: 257/739 - (34%)
• Gaps: 206/739 - (27%)

  Fly    38 IEEMSPPPAAPPRPSP-----------------------PPTVKL-------------------- 59
            |:.:||.|:||...||                       ||.||.
Human   299 IQPLSPQPSAPIASSPAIDMPPQSETISSPMPQTHVSGTPPPVKASFSSPTVSAPANVNTTSAPP 363

  Fly    60 ---------------NKCCHSGEYLNDGTC---IAGSEALWLPMVYLVQQQRFFEPHGASP---R 103
                           |:.....:.|:.|:.   :||.      |:..|.:.....|...:|   |
Human   364 VQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGE------MINQVSRLLHSPPDMLAPLAQR 422

  Fly   104 FLKFLPNTRPTCRKDQTTEIFRSRG-------ANVMLFPNGTLYVRERA-LMVQPSDYCVDWEVA 160
            .||.:.:.........||....|..       .|...|...|...::.| |.|.......:..:.
Human   423 LLKVVDDIGLQLNFSNTTISLTSPSLALAVIRVNASSFNTTTFVAQDPANLQVSLETQAPENSIG 487

  Fly   161 VVCLNDS----QPINALE-----DPDYAANPLVQQEPPKASLRLSKCCGKWGSY--NTQLQNCDL 214
            .:.|..|    .|.:.:|     ..::...|.:.|:|...:|.|.       ||  ::.:.|..:
Human   488 TITLPSSLMNNLPAHDMELASRVQFNFFETPALFQDPSLENLSLI-------SYVISSSVANLTV 545

  Fly   215 QPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSA 279
            :...:.....|..::|...|.:.:..:.  |.|:.||   .|.|.|
Human   546 RNLTRNVTVTLKHINPSQDELTVRCVFW--DLGRNGG---RGGWSD------------------- 586

  Fly   280 GQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNL--QKAVLTG----GILV 338
             ..|....:|..|. |..|.||           .|.|..::.:....|  |...||.    |..:
Human   587 -NGCSVKDRRLNET-ICTCSHL-----------TSFGVLLDLSRTSVLPAQMMALTFITYIGCGL 638

  Fly   339 SIVFLSATLVAGFLLPAVHHALHWR--CQICYVTCLLFGKILLAIEELSS--SLQPGSAACHTLA 399
            |.:|||.|||.......:......:  .|:| ...||...:.|    |.|  :|......|.::|
Human   639 SSIFLSVTLVTYIAFEKIRRDYPSKILIQLC-AALLLLNLVFL----LDSWIALYKMQGLCISVA 698

  Fly   400 ITMQFFFLAAFFWLNTMCFNIWW----TFRDFRPSSLERNQEALRRYL--YSLYAWGGPLLITFV 458
            :.:.:|.|.:|.|:....|:::.    .|..:           :|:|:  :.:..||.|.::..:
Human   699 VFLHYFLLVSFTWMGLEAFHMYLALVKVFNTY-----------IRKYILKFCIVGWGVPAVVVTI 752

  Fly   459 AACVDQLPETTLLRPGFGQL-------YCWFDNRNLSIFAYFY----GPIGLLLCANIALFVSTT 512
            ...:.  |:...| ..:|:.       :||.:|.     |.||    |...::...|:::|:...
Human   753 ILTIS--PDNYGL-GSYGKFPNGSPDDFCWINNN-----AVFYITVVGYFCVIFLLNVSMFIVVL 809

  Fly   513 HQLTCGLWKRDDVKSSSEKSALG-RVCLKLVVVMGVTWIADILSWLVGGPHGVWF--FTDLINAL 574
            .|| |.:.|:..:.:..:.|... |....|..::|:||.....:|   ||..|.|  ...:.|.|
Human   810 VQL-CRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAW---GPVNVTFMYLFAIFNTL 870

  Fly   575 QGVFIFIVVGCQP-----QVWTACRRIFCPRLR----HDITNT-TNGVQHSSSSQGLPSMAGGTE 629
            ||.||||.. |..     :.|.  |.:.|.:||    .|.:.| |||::..:.:||:.|.:...:
Human   871 QGFFIFIFY-CVAKENVRKQWR--RYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQ 932

  Fly   630 ITQNTTTTTT--TTNTTATHMPSN 651
            .:.|:|.:||  ..|..:.|...|
Human   933 SSSNSTNSTTLLVNNDCSVHASGN 956

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	62/277 (22%)
ADGRG2	NP_001073327.1	GPS	569..612	CDD:280071	16/79 (20%)
		7tm_4	625..875	CDD:304433	62/277 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810