DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl1 and adgrf8

DIOPT Version :9

Sequence 1:NP_001285340.1 Gene:mthl1 / 32637 FlyBaseID:FBgn0030766 Length:676 Species:Drosophila melanogaster
Sequence 2:XP_021324214.1 Gene:adgrf8 / 100537224 ZFINID:ZDB-GENE-130531-41 Length:1719 Species:Danio rerio


Alignment Length:359 Identity:79/359 - (22%)
Similarity:135/359 - (37%) Gaps:70/359 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 VLTGGILVSIVFLSATL-VAGFLLPAVHHALHWR-----------------------------CQ 365
            :|...||..|.::..|: :...:|..:..|:.||                             ..
Zfish  1384 ILDSLILAYITYIGVTISMISLVLCLIIEAIVWRSVTSARGVTVVSSYMRHISLVNIALSLLIAN 1448

  Fly   366 ICYVTCLLFGKILLAIEELSSSLQPGSAACHTLAITMQFFFLAAFFW-LNTMCFNIWWTFRDFRP 429
            :|::       |..||.:|......|  .|..:...:.||:||.||| |.:....::.|...|..
Zfish  1449 VCFI-------IGAAISDLEKPTPVG--RCSPVVFFIHFFYLAVFFWMLISGMLLLYMTVMVFGQ 1504

  Fly   430 SSLERNQEALRRYLYSL-YAWGGPLLITFVAACVDQLPETTLLRPGFGQLYCWFD-NRNLSIFAY 492
            .|      .::....|. ..:|.||||..:.......|:..:.:..     ||.: |.:.::.|:
Zfish  1505 MS------RIKMIAISFPVGYGAPLLIASITVASTAGPQNYVSKQA-----CWLNWNESRALLAF 1558

  Fly   493 FYGPIGLLLCANIALFVSTTHQLTCGLWKRDDVKSSSEKSALGRV--CLK-LVVVMGVTW---IA 551
            ....:.::....:.|.|.....|..|:   ......|||:....|  |:. |..:.|:||   |.
Zfish  1559 VIPALTIVAINLVVLVVVLYKMLGTGV---GAATQPSEKNTFFVVVRCVAFLTPLFGLTWGFGIG 1620

  Fly   552 DILSWLVGGPHGVWFFTDLINALQGVFIFIVVG--CQPQVWTACR-RIFCPRLRHDITNTTNGVQ 613
            .:||..:    ||.....|:||.||.|| ::.|  ...:|..|.| ::...:|...||.:|:|..
Zfish  1621 TMLSSAL----GVHVLFTLLNAFQGFFI-LLFGTILDAKVREALRGKLQIDKLASRITQSTSGGA 1680

  Fly   614 HSSSSQGLPSMAGGTEITQNTTTTTTTTNTTATH 647
            .||:.|..|..........|.|:..|:...:.::
Zfish  1681 SSSAGQRGPRRNVYNVSDPNNTSRFTSEGVSGSY 1714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl1NP_001285340.1 7tm_4 329..579 CDD:304433 61/286 (21%)
adgrf8XP_021324214.1 EGF_CA 156..189 CDD:214542
EGF_CA 324..357 CDD:214542
EGF_CA 508..>540 CDD:214542
EGF_CA 673..706 CDD:214542
Ig 899..968 CDD:325142
GPS 1337..1379 CDD:307782
7tm_GPCRs 1387..1660 CDD:333717 65/300 (22%)
TM helix 1 1390..1414 CDD:320095 4/23 (17%)
TM helix 2 1434..1455 CDD:320095 2/27 (7%)
TM helix 3 1470..1492 CDD:320095 8/21 (38%)
TM helix 4 1513..1529 CDD:320095 6/15 (40%)
TM helix 5 1551..1574 CDD:320095 1/22 (5%)
TM helix 6 1598..1623 CDD:320095 7/24 (29%)
TM helix 7 1627..1652 CDD:320095 10/29 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4193
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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