Protein Alignment mbt and SLK

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 95/264 - (35%)
• Similarity: 151/264 - (57%)
• Gaps: 7/264 - (2%)

  Fly   363 DPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVE 427
            :|.:..:...::|:|:.|.|..|.:|.|....|.|.:|.:.::..|....|:.|:....|||||:
Human    29 NPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK 93

  Fly   428 TYSSFLVNDELWVVMEYLEGGALTDIVTHSR--MDEEQIATVCKQCLKALAYLHSQGVIHRDIKS 490
            ...:|...:.||:::|:..|||:..::....  :.|.||..||||.|.||.|||...:||||:|:
Human    94 LLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKA 158

  Fly   491 DSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVI-----SRLPYGPEVDIWSLGI 550
            .:||...||.:||:|||..|:.::.:.:|.|.:||||||:|||:     ...||..:.|:|||||
Human   159 GNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGI 223

  Fly   551 MVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLA 615
            .:|||.:.|||.....|::.:.:|...:||.|....:.|...:.||.:.|.::...|.|.::||.
Human   224 TLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQ 288

  Fly   616 HPFL 619
            |||:
Human   289 HPFV 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	95/264 (36%)
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	95/264 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760
		PKK	852..990	CDD:463600
		PKK	1020..1160	CDD:463600