DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and TAOK2

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_011544284.1	Gene:	TAOK2 / 9344	HGNCID:	16835	Length:	1242	Species:	Homo sapiens

Alignment Length:	311	Identity:	109/311 - (35%)
Similarity:	162/311 - (52%)	Gaps:	22/311 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 SGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVK 397
            :||.||..| |..:....|:         .||.:......:||.||.|.|..|.|......||:|
Human     3 AGGRAGSLK-DPDVAELFFK---------DDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIK 57

  Fly   398 KMDLRKQQRREL---LFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR- 458
            ||....:|..|.   :..||..::...|||.::....:|.....|:||||..|.|...:..|.:
Human    58 KMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKP 122

  Fly   459 MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLV 523
            :.|.:||.|....|:.||||||..:||||:|:.:|||:..|.|||.|||..:.::    ...|.|
Human   123 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA----PANSFV 183

  Fly   524 GTPYWMSPEVISRL---PYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNA 585
            ||||||:||||..:   .|..:||:|||||..||:.:.:||.||...:.|:..|...:.|.|::.
Human   184 GTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSG 248

  Fly   586 HKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNAR 636
            | .|...::|:|..|.:.|..|.|:..||.|.|:.:..||::::.|::..:
Human   249 H-WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	99/266 (37%)
		S_TKc	372..619	CDD:214567	96/253 (38%)
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	104/301 (35%)
TAOK2	XP_011544284.1	S_TKc	28..281	CDD:214567	96/257 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910