DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and MYLK3

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_872299.2	Gene:	MYLK3 / 91807	HGNCID:	29826	Length:	819	Species:	Homo sapiens

Alignment Length:	627	Identity:	150/627 - (23%)
Similarity:	247/627 - (39%)	Gaps:	128/627 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PHHNNNKADTTSLNSSSTMMMGS---MAPMNPMAPGAHPMMS-----HGPGMMMPPET--GGIVL 132
            |...:.|||         ::.|:   :.|:.....||.|..:     .|.|:..|.:.  |.:.|
Human   187 PGEESQKAD---------VLEGTAERLPPIRASGLGADPAQAVVSPGQGDGVPGPAQAFPGHLPL 242

  Fly   133 PKTSHVAR-----SNSLRSS-----SPPRVRRVANVPPSVPEEEGPPAAG--------------- 172
            | |...|:     |.:||:.     :|.||..|:      |..|..|.||
Human   243 P-TKVEAKAPETPSENLRTGLELAPAPGRVNVVS------PSLEVAPGAGQGASSSRPDPEPLEE 300

  Fly   173 ----TPGVGGASSGGFKPPGAHPSLLYNSQHAHANGATGP-LAVRTDQTN-----LQQYRSNL-- 225
                |||.|....|   |||    |...::..|:.|.|.| :::...:.:     |...|.:|
Human   301 GTRLTPGPGPQCPG---PPG----LPAQARATHSGGETPPRISIHIQEMDTPGEMLMTGRGSLGP 358

  Fly   226 ---------------APPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSG----------GSY 265
                           .||..|...|...|.|......|.|.......:.:.|          |:.
Human   359 TLTTEAPAAAQPGKQGPPGTGRCLQAPGTEPGEQTPEGARELSPLQESSSPGGVKAEEEQRAGAE 423

  Fly   266 PPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSASRASSSSGGASSAAQQAS 330
            |...|:..:......:....|..|.::|  ...:|.|..     ..|:||...   |.:..:...
Human   424 PGTRPSLARSDDNDHEVGALGLQQGKSP--GAGNPEPEQ-----DCAARAPVR---AEAVRRMPP 478

  Fly   331 GASGGAA---GQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGR 392
            ||..|:.   ..|.......| :..:..:..:|||  .|...| ..:|.|..|.|...|:||||.
Human   479 GAEAGSVVLDDSPAPPAPFEH-RVVSVKETSISAG--YEVCQH-EVLGGGRFGQVHRCTEKSTGL 539

  Fly   393 QVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHS 457
            .:|.|.:.::..:.||.:.||:.||....|.|:::.|.:|.......:||||::||.|.|.:|..
Human   540 PLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDE 604

  Fly   458 R--MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLA--ADGRVKLSDFGFCAQVSQELPK 518
            :  :.|..:....:|..:.:.|||...::|.|:|.::||..  ...::|:.|||...:..   |:
Human   605 KYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYK---PR 666

  Fly   519 RKSLV--GTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRI----RDM 577
            .|..|  |||.:::|||::........|:||:|::...::.|..||..|...:.|..|    .|.
Human   667 EKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDF 731

  Fly   578 QPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL 619
            .....:.   :|...:.|:.|:||::.:.|.:|.:.|.|.:|
Human   732 DADTFEG---LSEEAKDFVSRLLVKEKSCRMSATQCLKHEWL 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	79/270 (29%)
		S_TKc	372..619	CDD:214567	73/256 (29%)
MYLK3	NP_872299.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..334		41/169 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..462		20/121 (17%)
		STKc_MLCK3	510..770	CDD:271094	78/268 (29%)
		S_TKc	513..770	CDD:214567	75/263 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000