Protein Alignment mbt and STE20

DIOPT Version :9

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_011856.1
• Gene: STE20 / 856382
• SGDID: S000000999
• Length: 939
• Species: Saccharomyces cerevisiae
• Alignment Length: 650
• Identity: 210/650 - (32%)
• Similarity: 307/650 - (47%)
• Gaps: 121/650 - (18%)

  Fly    11 ISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTEILDLKTI 75
            ||.|.|.:|..|.|.|.:..:|.|||.:|..::.::.|.|...:.         ....::|:...
Yeast   337 ISTPYNAKHIHHVGVDSKTGEYTGLPEEWEKLLTSSGISKREQQQ---------NMQAVMDIVKF 392

  Fly    76 VRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMA--PGAHPMMSHGPGMMMPPETGGIVLPKTSHV 138
            .:        |.|..|....|    ....|...  ||:       |.:..||
Yeast   393 YQ--------DVTETNGEDKM----FKTFNTTTGLPGS-------PQVSTPP------------- 425

  Fly   139 ARSNSLRSSSPPRVRRVANVPPSVPEEEG-PPAAGTPGVGGASSGGFKPPGAHPSLLYNSQHAHA 202
              :||..           ..|||..:... ....|||......|         |:|  |:..:.|
Yeast   426 --ANSFN-----------KFPPSTSDSHNYGSRTGTPMSNHVMS---------PTL--NTDSSSA 466

  Fly   203 NGATGPLAVRTDQTNLQQYRSNLAPPSGGS----------MPQQQQTSPVGSVASGTRSNHSHTN 257
            ||...|            .|....|||..|          |......||:....:.|..|.:..|
Yeast   467 NGKFIP------------SRPAPKPPSSASASAPIIKSPVMNSAANVSPLKQTHAPTTPNRTSPN 519

  Fly   258 NGNSGGS---------YPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKS-A 312
            ..:...:         .||:.||.                ...:|:...||.    .|.:|:| .
Yeast   520 RSSISRNATLKKEEQPLPPIPPTK----------------SKTSPIISTAHT----PQQVAQSPK 564

  Fly   313 SRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEG 377
            :.|..:....:|...||...|.....:.::::....:|..|.|..:.|.|||.....:..|||:|
Yeast   565 APAQETVTTPTSKPAQARSLSKELNEKKREERERRKKQLYAKLNEICSDGDPSTKYANLVKIGQG 629

  Fly   378 STGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVM 442
            ::|.|..|.:..|...||:|:|:|.||.::||:.||:::|:...|||||....|:::..:|||:|
Yeast   630 ASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIM 694

  Fly   443 EYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFG 507
            ||:|||:|||:|||..:.|.||..||::.|..|.:|||:||:|||||||:|||:.:|.:||:|||
Yeast   695 EYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFG 759

  Fly   508 FCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMR 572
            ||||:::...||.::|||||||:|||:||..|||:|||||||||:|||::||||:.||.||:|:.
Yeast   760 FCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALY 824

  Fly   573 RIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQ-AGPPSLLVPLMRNAR 636
            .|.....|.||....:|..|:.|||..|..:|..||:|.|||...::.: |...|.|.||::.||
Yeast   825 LIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSLAPLVKLAR 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	15/42 (36%)
		STKc_PAK_II	360..620	CDD:270815	132/259 (51%)
		S_TKc	372..619	CDD:214567	128/246 (52%)
STE20	NP_011856.1	PBD	336..394	CDD:395634	16/65 (25%)
		STKc_PAK	619..872	CDD:270789	128/252 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910