DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and MAP4K3

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_003609.2	Gene:	MAP4K3 / 8491	HGNCID:	6865	Length:	894	Species:	Homo sapiens

Alignment Length:	281	Identity:	112/281 - (39%)
Similarity:	173/281 - (61%)	Gaps:	8/281 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 VSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHP 423
            :|..:|:|:.:...:||.|:.|.|..|.:.:||...|:|.:.|...:...::..|:::|:|..||
Human     7 LSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHP 71

  Fly   424 NIVETYSSFLVNDELWVVMEYLEGGALTDI--VTHSRMDEEQIATVCKQCLKALAYLHSQGVIHR 486
            |||..:.|:|..|:||:.||:..||:|.||  || ..:.|.|||.|.::.|:.|.||||:|.:||
Human    72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT-GPLSELQIAYVSRETLQGLYYLHSKGKMHR 135

  Fly   487 DIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS---RLPYGPEVDIWSL 548
            |||..:|||..:|.|||:|||..||::..:.||||.:||||||:|||.:   :..|....|:|::
Human   136 DIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAV 200

  Fly   549 GIMVIEMVDGEPPFFNEPPLQAMRRI--RDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAA 611
            ||..||:.:.:||.|:..|::|:..:  .:.|||.||:..|.|.....|:...|.::|.:|.||.
Human   201 GITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAE 265

  Fly   612 ELLAHPFLRQAGPPSLLVPLM 632
            :||.|||:.|....||.:.|:
Human   266 KLLQHPFVTQHLTRSLAIELL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	108/266 (41%)
		S_TKc	372..619	CDD:214567	104/253 (41%)
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	104/258 (40%)
		S_TKc	16..273	CDD:214567	104/257 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..536
		CNH	561..874	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910