DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and SIK1

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_564955.1	Gene:	SIK1 / 843253	AraportID:	AT1G69220	Length:	836	Species:	Arabidopsis thaliana

Alignment Length:	556	Identity:	155/556 - (27%)
Similarity:	242/556 - (43%)	Gaps:	102/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PK----TSHVARSNSLRSSSPPRVRRVANVPPSVPEE-EGPPAAGTPGVGGASSG---------G 183
            ||    ::.|..|:|.......|.:|.|.     ||| |......|....|.|.|         .
plant    16 PKPDIYSTFVVHSDSDSDQGRDRDKRKAK-----PEEDENVDLYATMVYKGDSDGEGEEDDDDDS 75

  Fly   184 FKPP---------GAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQT 239
            ..||         |...||.|:......:|..|.:.|:||
plant    76 MLPPLLKRLPKDFGGGASLDYDDDDGDESGDFGTMIVKTD------------------------- 115

  Fly   240 SPVGSVASGTRSNHSHTNNGNSG----GSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHP 300
                      ||:||..|:..|.    |..|........::...::..::..|.:..
plant   116 ----------RSSHSKKNSPYSSKPRMGVSPRRRARGGDEESSDEEDEEEDDDDDDG-------- 162

  Fly   301 HPHHHQHLAKS---------------------ASRASSSSGGASSAAQQASGASGGAAGQPKQDQ 344
              .:...:.||                     ||...|:.||.:.....:|.:|.......::.|
plant   163 --DYGTFVVKSKDKKGKKKDKEIDMTTMGRAVASMQKSNFGGKTRKLDPSSSSSKLHGEDNRKMQ 225

  Fly   345 RLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRK-QQRRE 408
            :...:....:|...::..||....:..|::|:||.|:|..|.|..|...||||.:.|.: ::..|
plant   226 QQNSKMSTTSLPDSITREDPTTKYEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYE 290

  Fly   409 LLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDI--VTHSRMDEEQIATVCKQC 471
            .:..|:.:::..:|||:|....|:...|.||:||||..||::.|:  ||...::|.|||.:|::.
plant   291 EIRGEIEMLQQCNHPNVVRYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREA 355

  Fly   472 LKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISR 536
            ||.||||||...:|||||..:|||...|.|||.|||..||:::.:.||.:.:|||:||:||||..
plant   356 LKGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQE 420

  Fly   537 LPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLV 601
            ..|..:||:|:||:..|||.:|.||..:..|::.:..|.....|.|::..|.|.....|:.:.|.
plant   421 NRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEKWSLVFHDFVAKCLT 485

  Fly   602 RDPAQRATAAELLAHPFLRQAGP-PSLLVPLMRNAR 636
            ::|..|.||||:|.|.|:.:... .|.:.|.:..:|
plant   486 KEPRLRPTAAEMLKHKFVERCKTGASAMSPKIEKSR 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	105/262 (40%)
		S_TKc	372..619	CDD:214567	102/249 (41%)
SIK1	NP_564955.1	STKc_MAP4K3_like	248..503	CDD:270788	102/254 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010