DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and STK24

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_016876283.1	Gene:	STK24 / 8428	HGNCID:	11403	Length:	517	Species:	Homo sapiens

Alignment Length:	313	Identity:	119/313 - (38%)
Similarity:	175/313 - (55%)	Gaps:	18/313 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GASGGAAGQPKQDQR---------LTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIAT 386
            |.:||..||....:|         :...::|..|:     .||.|......|||:||.|.|....
Human    69 GQAGGRPGQGGDGERAWTRPGPSGVGRVEWRKNLK-----ADPEELFTKLEKIGKGSFGEVFKGI 128

  Fly   387 DKSTGRQVAVKKMDLRK-QQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGAL 450
            |..|.:.||:|.:||.: :...|.:..|:.::.....|.:.:.|.|:|.:.:||::||||.||:.
Human   129 DNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSA 193

  Fly   451 TDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQE 515
            .|::....:||.||||:.::.||.|.||||:..||||||:.::||:..|.|||:|||...|::..
Human   194 LDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDT 258

  Fly   516 LPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPP 580
            ..||.:.||||:||:||||.:..|..:.|||||||..||:..||||.....|::.:..|....||
Human   259 QIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPP 323

  Fly   581 NLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPF-LRQAGPPSLLVPLM 632
            .|:..:  |..|:.|::..|.::|:.|.||.|||.|.| ||.|...|.|..|:
Human   324 TLEGNY--SKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	105/261 (40%)
		S_TKc	372..619	CDD:214567	102/248 (41%)
STK24	XP_016876283.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910