DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and MAP3KA

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_564635.1	Gene:	MAP3KA / 841792	AraportID:	AT1G53570	Length:	609	Species:	Arabidopsis thaliana

Alignment Length:	443	Identity:	121/443 - (27%)
Similarity:	194/443 - (43%)	Gaps:	95/443 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 PPMYPTSHQQQQQQQQ-----QAKQGGDQNQNPLHPHAHPHP-------HHHQHLAKSASRAS-- 316
            ||:.||.....:..::     .|..|.|.:......|..|.|       ||..|::.|.|.::
plant    36 PPLTPTRGGTPRCSREFAGASSAFSGFDSDSTEKKGHPLPRPLLSPVSIHHQDHVSGSTSGSTSV 100

  Fly   317 ---SSSGGASSAAQQASGASGG-----AAGQPKQDQRLT--------------HEQFRAALQMVV 359
               ||||.|...:|..:....|     .|..|:..:|::              |::....:.:..
plant   101 SSVSSSGSADDQSQLVASRGRGDVKFNVAAAPRSPERVSPKAATITTRPTSPRHQRLSGVVSLES 165

  Fly   360 SAG---DPRENLD-----------------HFNKI--------------------GEGSTGTVCI 384
            |.|   |.|.:.:                 |.::|                    |.|:.|.|.:
plant   166 STGRNDDGRSSSECHPLPRPPTSPTSPSAVHGSRIGGGYETSPSGFSTWKKGKFLGSGTFGQVYL 230

  Fly   385 ATDKSTGRQVAVKKM-----DLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEY 444
            ..:...|:..|:|::     |...::..:.|..|:.::....|||||:.|.|.|..:.|.|.:||
plant   231 GFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLCHPNIVQYYGSELSEETLSVYLEY 295

  Fly   445 LEGGALTDIV-THSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGF 508
            :.||::..:: .:....|..|....:|.|..|||||.:..:|||||..:||:..:|.:||:|||.
plant   296 VSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGM 360

  Fly   509 CAQVSQELPKRKSLVGTPYWMSPEVI-SRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMR 572
            ...|: ......|..|:||||:|||: |:..|...|||||||..::||...:||:.....:.|:.
plant   361 AKHVT-AFSTMLSFKGSPYWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIF 424

  Fly   573 RIRDMQ-----PPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLR 620
            :|.:.:     |.:|.|..|      :|:...|.|:|..|.||::||.|||||
plant   425 KIGNSKDTPEIPDHLSNDAK------NFIRLCLQRNPTVRPTASQLLEHPFLR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	93/311 (30%)
		S_TKc	372..619	CDD:214567	87/278 (31%)
MAP3KA	NP_564635.1	STKc_MEKK1_plant	213..470	CDD:270802	86/263 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960