DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and MAPKKK5

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_569040.1	Gene:	MAPKKK5 / 836819	AraportID:	AT5G66850	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	616	Identity:	160/616 - (25%)
Similarity:	246/616 - (39%)	Gaps:	159/616 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 SSSTMMMG-----SMAPMNPMAPGAHPMMSHGPGMMMPPETGGIVLPKTSHVARSNSLRSSSPPR 151
            ||||...|     |.....|.:|.|.|:    |..:..||..||   :.:..||....|...|.|
plant    77 SSSTFDSGLTRSPSAFTAVPRSPSAVPL----PLPLPLPEVAGI---RNAANARGLDDRDRDPER 134

  Fly   152 VRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQT 216
            :       .|.....|||....       :|||         ..:|:.|..|.:....:.|
plant   135 L-------ISDRTSSGPPLTSV-------NGGF---------ARDSRKATENSSYQDFSPR---- 172

  Fly   217 NLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSH----------TNNG--------NSGG 263
            |...|..|:...|..:.|..   ||   |.|..|.:..|          :|..        ::.|
plant   173 NRNGYWVNIPTMSAPTSPYM---SP---VPSPQRKSTGHDLPFFYLPPKSNQAWSAPDMPLDTSG 231

  Fly   264 SYPPMY-----------------PTSHQQQQQQQQQAKQGG------------DQNQNPLHP--- 296
            ..||.:                 |.|.::|.:..|.::...            |...:||||
plant   232 LPPPAFYDITAFSTDNSPIHSPQPRSPRKQIRSPQPSRPSSPLHSVDSSAPPRDSVSSPLHPRLS 296

  Fly   297 -----------HAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQP-KQDQRLTHE 349
                       :.||.|     |...|:  .|||..||..:.||          | |.|....:.
plant   297 TDVTNGRRDCCNVHPLP-----LPPGAT--CSSSSAASVPSPQA----------PLKLDSFPMNS 344

  Fly   350 QFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDL-----RKQQRREL 409
            |::..                 ..||.|:.|:|.:|::..||...|:|:::|     :..:..:.
plant   345 QWKKG-----------------KLIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQ 392

  Fly   410 LFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTH--SRMDEEQIATVCKQCL 472
            |..|:.::.:..|||||:.:.|..|.|..::.:||:..|::...:..  ..|.|..:....:..|
plant   393 LEQEIKLLSNLQHPNIVQYFGSETVEDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHIL 457

  Fly   473 KALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEV---I 534
            ..|||||::..:|||||..::|:.|.|.|||:|||....::.:... .||.|:||||:||:   :
plant   458 SGLAYLHNKKTVHRDIKGANLLVDASGVVKLADFGMAKHLTGQRAD-LSLKGSPYWMAPELMQAV 521

  Fly   535 SRLPYGPE----VDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSF 595
            .:....|:    |||||||..:|||..|:||:.......||.::....||   ....:||..:.|
plant   522 MQKDSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDSPP---IPESMSPEGKDF 583

  Fly   596 LDRMLVRDPAQRATAAELLAHPFLRQAGPPS 626
            |.....|:||:|.||:.||.|.||:.:..|:
plant   584 LRLCFQRNPAERPTASMLLEHRFLKNSLQPT 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	87/273 (32%)
		S_TKc	372..619	CDD:214567	86/260 (33%)
MAPKKK5	NP_569040.1	PKc_like	346..607	CDD:419665	86/281 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960