Protein Alignment mbt and Pak4

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_081746.1
• Gene: Pak4 / 70584
• MGIID: 1917834
• Length: 593
• Species: Mus musculus
• Alignment Length: 665
• Identity: 335/665 - (50%)
• Similarity: 403/665 - (60%)
• Gaps: 103/665 - (15%)

  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.||||:..||.|||||||||||||:.|.|:.|||.||.|:     |.:|:.||.||:||:.||
Mouse     1 MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSL-----IEESARRPKPLIDPACIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130
            ..:....|||||       ....:.:.:.|:::.....|:
Mouse    61 SIQPGAPKTIVR-------GSKGAKDGALTLLLDEFENMS------------------------- 93

  Fly   131 VLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLY 195
                   |.||||||..|||...| |:....:.||...||...|...|:.:..
Mouse    94 -------VTRSNSLRRESPPPPAR-AHQENGMLEERAAPARMAPDKAGSRARA------------ 138

  Fly   196 NSQHAHANGATG----------PLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGT- 249
             :.|:.|...:|          |.:.|......|:...:..|.||   |......| ||:.|||
Mouse   139 -TGHSEAGSGSGDRRRVGPEKRPKSSRDGPGGPQEASRDKRPLSG---PDVSTPQP-GSLTSGTK 198

  Fly   250 -----------RSNHSHTNNGNSGGSY--PPMYPT-----SHQQQQQQQQQAKQGGDQNQNPLHP 296
                       |::..|...|..|..:  .|..|:     :.|.....:...:..|..:...|.|
Mouse   199 LAAGRPFNTYPRADTDHPPRGAQGEPHTMAPNGPSATGLAAPQSSSSSRPPTRARGAPSPGVLGP 263

  Fly   297 HAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSA 361
            ||     ....||..| ||.     |:.|...|.|..|..:.| ::.||::|||||||||:||..
Mouse   264 HA-----SEPQLAPPA-RAL-----AAPAVPPAPGPPGPRSPQ-REPQRVSHEQFRAALQLVVDP 316

  Fly   362 GDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIV 426
            ||||..||:|.||||||||.|||||.:|:|:.|||||||||||||||||||||||||||.|.|:|
Mouse   317 GDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVV 381

  Fly   427 ETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSD 491
            |.|:|:||.||||||||:||||||||||||:||:|||||.||...|:|||.||:|||||||||||
Mouse   382 EMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSD 446

  Fly   492 SILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMV 556
            ||||..||||||||||||||||:|:|:|||||||||||:||:||||||||||||||||:||||||
Mouse   447 SILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMV 511

  Fly   557 DGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQ 621
            |||||:||||||:||:.|||..||.|||.||.||.|:.||||:|||||||||||||||.||||.:
Mouse   512 DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTK 576

  Fly   622 AGPPSLLVPLMRNAR 636
            ||||:.:|||||..|
Mouse   577 AGPPASIVPLMRQHR 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	25/44 (57%)
		STKc_PAK_II	360..620	CDD:270815	208/259 (80%)
Pak4	NP_081746.1	CRIB_PAK_like	10..48	CDD:238526	25/42 (60%)
		Linker	25..322		101/370 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..303		58/237 (24%)
		Protein Kinases, catalytic domain	302..593	CDD:473864	230/290 (79%)