DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbt and Pak4

DIOPT Version :9

Sequence 1:NP_523375.2 Gene:mbt / 32631 FlyBaseID:FBgn0025743 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_081746.1 Gene:Pak4 / 70584 MGIID:1917834 Length:593 Species:Mus musculus


Alignment Length:665 Identity:335/665 - (50%)
Similarity:403/665 - (60%) Gaps:103/665 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.||||:..||.|||||||||||||:.|.|:.|||.||.|:     |.:|:.||.||:||:.||
Mouse     1 MFGKKKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSL-----IEESARRPKPLIDPACIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130
            ..:....|||||       ....:.:.:.|:::.....|:                         
Mouse    61 SIQPGAPKTIVR-------GSKGAKDGALTLLLDEFENMS------------------------- 93

  Fly   131 VLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLY 195
                   |.||||||..|||...| |:....:.||...||...|...|:.:..            
Mouse    94 -------VTRSNSLRRESPPPPAR-AHQENGMLEERAAPARMAPDKAGSRARA------------ 138

  Fly   196 NSQHAHANGATG----------PLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGT- 249
             :.|:.|...:|          |.:.|......|:...:..|.||   |......| ||:.||| 
Mouse   139 -TGHSEAGSGSGDRRRVGPEKRPKSSRDGPGGPQEASRDKRPLSG---PDVSTPQP-GSLTSGTK 198

  Fly   250 -----------RSNHSHTNNGNSGGSY--PPMYPT-----SHQQQQQQQQQAKQGGDQNQNPLHP 296
                       |::..|...|..|..:  .|..|:     :.|.....:...:..|..:...|.|
Mouse   199 LAAGRPFNTYPRADTDHPPRGAQGEPHTMAPNGPSATGLAAPQSSSSSRPPTRARGAPSPGVLGP 263

  Fly   297 HAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSA 361
            ||     ....||..| ||.     |:.|...|.|..|..:.| ::.||::|||||||||:||..
Mouse   264 HA-----SEPQLAPPA-RAL-----AAPAVPPAPGPPGPRSPQ-REPQRVSHEQFRAALQLVVDP 316

  Fly   362 GDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIV 426
            ||||..||:|.||||||||.|||||.:|:|:.|||||||||||||||||||||||||||.|.|:|
Mouse   317 GDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYRHENVV 381

  Fly   427 ETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSD 491
            |.|:|:||.||||||||:||||||||||||:||:|||||.||...|:|||.||:|||||||||||
Mouse   382 EMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSD 446

  Fly   492 SILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMV 556
            ||||..||||||||||||||||:|:|:|||||||||||:||:||||||||||||||||:||||||
Mouse   447 SILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGVMVIEMV 511

  Fly   557 DGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQ 621
            |||||:||||||:||:.|||..||.|||.||.||.|:.||||:|||||||||||||||.||||.:
Mouse   512 DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQRATAAELLKHPFLTK 576

  Fly   622 AGPPSLLVPLMRNAR 636
            ||||:.:|||||..|
Mouse   577 AGPPASIVPLMRQHR 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbtNP_523375.2 CRIB_PAK_like 9..54 CDD:238526 25/44 (57%)
STKc_PAK_II 360..620 CDD:270815 208/259 (80%)
S_TKc 372..619 CDD:214567 200/246 (81%)
Pak4NP_081746.1 CRIB_PAK_like 10..48 CDD:238526 25/42 (60%)
Linker 25..322 101/370 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..303 58/237 (24%)
PKc_like 302..593 CDD:389743 230/290 (79%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 423 1.000 Domainoid score I622
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4300
Inparanoid 1 1.050 601 1.000 Inparanoid score I942
Isobase 1 0.950 - 0 Normalized mean entropy S1363
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131221at33208
OrthoFinder 1 1.000 - - FOG0001853
OrthoInspector 1 1.000 - - otm43475
orthoMCL 1 0.900 - - OOG6_105633
Panther 1 1.100 - - O PTHR48015
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3286
SonicParanoid 1 1.000 - - X1054
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.910

Return to query results.
Submit another query.