DRSC/TRiP Functional Genomics Resources

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Protein Alignment mbt and PAK5

DIOPT Version :9

Sequence 1:NP_523375.2 Gene:mbt / 32631 FlyBaseID:FBgn0025743 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_065074.1 Gene:PAK5 / 57144 HGNCID:15916 Length:719 Species:Homo sapiens


Alignment Length:759 Identity:355/759 - (46%)
Similarity:426/759 - (56%) Gaps:161/759 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.|||||..||.|||||||||||||.:|.|:.|||.||.|::.:     ::|||.|:||||.||
Human     1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLAD-----TANRPKPMVDPSCIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLN-------SSSTMMMGSMAPMNPMAP--GAHPMMSHGPGM 121
            |.::..:|||||   .|.....||:|       :.|.....|:...:|..|  ||   .||||| 
Human    61 PIQLAPMKTIVR---GNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGA---SSHGPG- 118

  Fly   122 MMPPETGGIVLP-------------------------------KTSHVARSNS------------ 143
             ...|.|.|...                               :.||.|:.|.            
Human   119 -HAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYY 182

  Fly   144 --------------------LRSSSPP--------RVRRVANVPPSVPEEEGPPAAGTPGVGGAS 180
                                |.|.|.|        ..:|.::..|.....:..|:. |.|..|.|
Human   183 SEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSR-TAGTSGCS 246

  Fly   181 SGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGS- 244
            .         .||.|:...      .||.....|:.....|.:..:|     .|..:|.|..|| 
Human   247 K---------ESLAYSESE------WGPSLDDYDRRPKSSYLNQTSP-----QPTMRQRSRSGSG 291

  Fly   245 -----VASGTRSNHSHTNNGNSGGSY-------------------------PPM-----YPTSHQ 274
                 :..|..:..:|. .|:|..||                         ||:     ||....
Human   292 LQEPMMPFGASAFKTHP-QGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPA 355

  Fly   275 QQQQQQQQAKQGGDQNQNPLHPHA-----HPHPHHHQHLAKSASRASSSSGGASSAAQQASGASG 334
            :..|.|.::......:|.|...|.     ||..........:||..||.|..:|:....:.|:| 
Human   356 KLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSS- 419

  Fly   335 GAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKM 399
                ..:|..|::|||||||||:|||.|||||.|.:|.||||||||.|||||:|.||:|||||||
Human   420 ----SDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480

  Fly   400 DLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQI 464
            |||||||||||||||||||||||.|:|:.|||:||.||||||||:||||||||||||:||:||||
Human   481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI 545

  Fly   465 ATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWM 529
            ||||...|:||:|||:|||||||||||||||.:|||:||||||||||||:|:|||||||||||||
Human   546 ATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM 610

  Fly   530 SPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQS 594
            :||||||||||.||||||||||||||:|||||:||||||||||||||..||.:|:.||||..|:.
Human   611 APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRG 675

  Fly   595 FLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNARHH 638
            |||.||||:|:|||||.|||.||||:.|||||.:|||||..|||
Human   676 FLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbtNP_523375.2 CRIB_PAK_like 9..54 CDD:238526 23/44 (52%)
STKc_PAK_II 360..620 CDD:270815 211/259 (81%)
S_TKc 372..619 CDD:214567 202/246 (82%)
PAK5NP_065074.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29 22/27 (81%)
CRIB_PAK_like 9..55 CDD:238526 27/50 (54%)
Linker 25..448 115/462 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..123 10/30 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..299 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..373 6/32 (19%)
STKc_PAK5 426..717 CDD:132989 234/290 (81%)
S_TKc 454..700 CDD:214567 202/245 (82%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 423 1.000 Domainoid score I619
eggNOG 1 0.900 - - E1_KOG0578
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 600 1.000 Inparanoid score I958
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131221at33208
OrthoFinder 1 1.000 - - FOG0001853
OrthoInspector 1 1.000 - - otm41424
orthoMCL 1 0.900 - - OOG6_105633
Panther 1 1.100 - - O PTHR48015
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3286
SonicParanoid 1 1.000 - - X1054
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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