Protein Alignment mbt and PAK5

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_065074.1
• Gene: PAK5 / 57144
• HGNCID: 15916
• Length: 719
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 355/759 - (46%)
• Similarity: 426/759 - (56%)
• Gaps: 161/759 - (21%)

  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.|||||..||.|||||||||||||.:|.|:.|||.||.|::.:     ::|||.|:||||.||
Human     1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLAD-----TANRPKPMVDPSCIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLN-------SSSTMMMGSMAPMNPMAP--GAHPMMSHGPGM 121
            |.::..:|||||   .|.....||:|       :.|.....|:...:|..|  ||   .|||||
Human    61 PIQLAPMKTIVR---GNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGA---SSHGPG- 118

  Fly   122 MMPPETGGIVLP-------------------------------KTSHVARSNS------------ 143
             ...|.|.|...                               :.||.|:.|.
Human   119 -HAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYY 182

  Fly   144 --------------------LRSSSPP--------RVRRVANVPPSVPEEEGPPAAGTPGVGGAS 180
                                |.|.|.|        ..:|.::..|.....:..|:. |.|..|.|
Human   183 SEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSR-TAGTSGCS 246

  Fly   181 SGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGS- 244
            .         .||.|:...      .||.....|:.....|.:..:|     .|..:|.|..||
Human   247 K---------ESLAYSESE------WGPSLDDYDRRPKSSYLNQTSP-----QPTMRQRSRSGSG 291

  Fly   245 -----VASGTRSNHSHTNNGNSGGSY-------------------------PPM-----YPTSHQ 274
                 :..|..:..:|. .|:|..||                         ||:     ||....
Human   292 LQEPMMPFGASAFKTHP-QGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPA 355

  Fly   275 QQQQQQQQAKQGGDQNQNPLHPHA-----HPHPHHHQHLAKSASRASSSSGGASSAAQQASGASG 334
            :..|.|.::......:|.|...|.     ||..........:||..||.|..:|:....:.|:|
Human   356 KLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSS- 419

  Fly   335 GAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKM 399
                ..:|..|::|||||||||:|||.|||||.|.:|.||||||||.|||||:|.||:|||||||
Human   420 ----SDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480

  Fly   400 DLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQI 464
            |||||||||||||||||||||||.|:|:.|||:||.||||||||:||||||||||||:||:||||
Human   481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI 545

  Fly   465 ATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWM 529
            ||||...|:||:|||:|||||||||||||||.:|||:||||||||||||:|:|||||||||||||
Human   546 ATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWM 610

  Fly   530 SPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQS 594
            :||||||||||.||||||||||||||:|||||:||||||||||||||..||.:|:.||||..|:.
Human   611 APEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRG 675

  Fly   595 FLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNARHH 638
            |||.||||:|:|||||.|||.||||:.|||||.:|||||..|||
Human   676 FLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	23/44 (52%)
		STKc_PAK_II	360..620	CDD:270815	211/259 (81%)
PAK5	NP_065074.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		22/27 (81%)
		CRIB_PAK_like	9..55	CDD:238526	27/50 (54%)
		Linker	25..448		115/462 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..123		10/30 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..299		10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..373		6/32 (19%)
		STKc_PAK5	426..717	CDD:132989	234/290 (81%)