DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and map3k3

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_688694.2	Gene:	map3k3 / 560211	ZFINID:	ZDB-GENE-070910-1	Length:	620	Species:	Danio rerio

Alignment Length:	659	Identity:	171/659 - (25%)
Similarity:	275/659 - (41%)	Gaps:	113/659 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSKKKKKPLISMPSNFEHR---VHTGFD---KRENKYVGLPLQWASI-------VGNNQILKSSN 53
            :...|.||:|  |::..:|   |...|:   :|.....|.|:|:..:       .|....|...|
Zfish    28 YDTAKTKPVI--PASSSNRLEDVRIKFEFCGERRILMFGRPVQFEEVQQKVKTFFGQQLDLHYMN 90

  Fly    54 RPL--PLVDPSEITPTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMS 116
            ..|  ||.|..::  .:.:||            .|.:|...|..:|:.:....|..:...|.:..
Zfish    91 NELSIPLRDQDDL--DKAIDL------------LDRSSNMKSIKIMLLTQEQSNASSSSHHTVCK 141

  Fly   117 HGPGMMMPPETGGIVLPKTS-------HVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTP 174
            . ..:.....||.:.....|       |...|.:...||||        |..|||.:...|....
Zfish   142 Q-VRIKTSQSTGDVSTAYQSSEPRGRHHSTSSQNTGRSSPP--------PGYVPERQQRIARQGS 197

  Fly   175 GVGGASSGGFKPPGAHPSLL--YNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQ 237
            .....|.|.|.|..:...:|  ::|.....:|:...|...:|..:|::.|::...    |.|..:
Zfish   198 YTSINSEGEFIPETSDQCVLDPWSSAENSVSGSCQSLDSNSDSPSLRKSRTHRIK----SYPDNR 258

  Fly   238 QTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTS--HQQQQQQQQ-----QAKQGGDQNQNPLH 295
            |.       ...|.||.:......||:||..|..|  |:...:.::     :..||   |...|.
Zfish   259 QD-------CSDRENHVYDKIVGKGGTYPRRYHVSMHHKDHSEGRRTFPRIRRPQG---NLFTLV 313

  Fly   296 PHAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVS 360
            |                ||.|.:....|..:.|........  :| ||:.:.|:...|.:..
Zfish   314 P----------------SRRSLNGSEESLGSWQLENTQSRL--RP-QDRAVPHKSPTAPVTW--- 356

  Fly   361 AGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDL---RKQQRREL--LFNEVVIMRDY 420
               .|..|     :|:|:.|.|.:..|..|||::|.|::..   ..:..:|:  |..|:.::::.
Zfish   357 ---RRGKL-----LGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNL 413

  Fly   421 HHPNIVETYSSFLVNDE--LWVVMEYLEGGALTD-IVTHSRMDEEQIATVCKQCLKALAYLHSQG 482
            ||..||:.|.....::|  |.:.|||:.||::.| :..:..:.|.......:|.|:.::||||..
Zfish   414 HHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNM 478

  Fly   483 VIHRDIKSDSILLAADGRVKLSDFGFCAQ---VSQELPKRKSLVGTPYWMSPEVISRLPYGPEVD 544
            ::|||||..:||..:.|.|||.|||...:   :.......:|:.||||||||||||...||.:.|
Zfish   479 IVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVISGEGYGRKAD 543

  Fly   545 IWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRAT 609
            :||||..|:||:..:||:.....:.|:.:|. .||.|.:....:|...:.|| |.:..:...|.:
Zfish   544 VWSLGCTVVEMLTEKPPWAEFEAMAAIFKIA-TQPTNPQLPSHISEHTRDFL-RCIFVEAKYRPS 606

  Fly   610 AAELLAHPF 618
            |.|||.|||
Zfish   607 AEELLRHPF 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	12/57 (21%)
		STKc_PAK_II	360..620	CDD:270815	91/270 (34%)
		S_TKc	372..619	CDD:214567	89/258 (34%)
map3k3	XP_688694.2	PB1_Mekk2_3	48..126	CDD:99726	19/91 (21%)
		STKc_MEKK3_like	356..615	CDD:270795	89/271 (33%)
		S_TKc	356..615	CDD:214567	89/271 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910