Protein Alignment mbt and map3k2

DIOPT Version :9

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: XP_686613.2
• Gene: map3k2 / 558321
• ZFINID: ZDB-GENE-120215-96
• Length: 623
• Species: Danio rerio
• Alignment Length: 672
• Identity: 167/672 - (24%)
• Similarity: 277/672 - (41%)
• Gaps: 140/672 - (20%)

  Fly     8 KPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPS---EITPTEI 69
            ||..|.|.| ::.|...|:.|               |..:||:.. ||:.|.|.|   ::...:.
Zfish    31 KPKASSPKN-QNDVRVKFEYR---------------GEKRILQFP-RPVSLEDLSAKAKVAFGQS 78

  Fly    70 LDLKTIVRPHHNNNK-----ADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGG 129
            :||      |:.||:     :....|:.:..::..|:          | |.|....:::|..:..
Zfish    79 MDL------HYTNNELVIPLSTQDDLDKAVELLDRSV----------H-MKSLKILLVLPSWSQN 126

  Fly   130 IVLPK---TSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHP 191
            .|..|   .:|....|: ..|:|.:...:|::.....:...|                 |||..|
Zfish   127 CVSSKDLLPTHDILDNT-DFSAPDKKSMLAHIGSQSTDRSSP-----------------PPGYIP 173

  Fly   192 SLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHT 256
            ..|   |....||:.  .::.::...:.:....:..|...|.|:...:....|:.|...|:
Zfish   174 DAL---QQVARNGSF--TSINSEGEFIPESMDQMLDPLSMSSPENSASGSCPSLDSPLDSD---- 229

  Fly   257 NNGNSGGSYPP-------MYPTSHQQQQQQQ----QQAKQGGDQNQNPLHPHAHPHPHHHQHLAK 310
                   :||.       .||.:||:..:..    ::..:||      .:|..:..|...|..:.
Zfish   230 -------TYPKSRMPRALSYPDNHQEFPEYDIPVFEKTGKGG------TYPRRYHIPFGLQDYSD 281

  Fly   311 S-----ASRASSSSGGASSAA------QQASGASGGAAGQPKQDQ---RLTHEQFRAALQMVVSA 361
            .     .:|.:.:.|..|..:      |..|.:||.:...|:.::   |........:....:|.
Zfish   282 GRKTFPRARRTQAHGFRSPVSFSPTEQQSPSTSSGSSIFTPELEEPGRRRRGSDIEPSSNPTLSV 346

  Fly   362 GD-------PR--ENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDL---RKQQRREL--LFN 412
            .|       ||  .|......:|:|:.|.|.:..|..|||::|||::..   ..:..:|:  |..
Zfish   347 MDISPPSRSPRAPTNWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPDSPETSKEVSALEC 411

  Fly   413 EVVIMRDYHHPNIVETYSSFLVNDE--LWVVMEYLEGGALTD-IVTHSRMDEEQIATVCKQCLKA 474
            |:.::::..|..||:.|.......|  |.:.|||:.||::.| :.::..:.|.......:|.|:.
Zfish   412 EIQLLKNLFHERIVQYYGCLRDTHEKTLSIFMEYMPGGSIKDQLKSYGALTENVTRKYTRQILEG 476

  Fly   475 LAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPK-------RKSLVGTPYWMSPE 532
            :.||||..::|||||..:||..:.|.|||.|||    .|:.|..       .||:.|||||||||
Zfish   477 VCYLHSNMIVHRDIKGANILRDSAGNVKLGDFG----ASRRLQTICLSGTGIKSVTGTPYWMSPE 537

  Fly   533 VISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLD 597
            |||...||.:.||||:|..|:||:...||:.....:.|:.:|. .||.|......||...:.||.
Zfish   538 VISGEGYGRKADIWSIGCTVVEMLTQRPPWAEFEAMAAIFKIA-TQPTNPTLPPHVSDHCRDFLK 601

  Fly   598 RMLVRDPAQRATAAELLAHPFL 619
            |:.| :..||..|.:||.|.|:
Zfish   602 RIFV-ETKQRPAAEDLLRHTFV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	10/44 (23%)
		STKc_PAK_II	360..620	CDD:270815	98/284 (35%)
		S_TKc	372..619	CDD:214567	92/261 (35%)
map3k2	XP_686613.2	PB1_Mekk2_3	43..121	CDD:99726	21/110 (19%)
		STKc_MEKK2	359..622	CDD:270818	93/268 (35%)
		S_TKc	362..622	CDD:214567	92/265 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910