DRSC/TRiP Functional Genomics Resources

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Protein Alignment mbt and Map3k14

DIOPT Version :10

Sequence 1:NP_523375.2 Gene:mbt / 32631 FlyBaseID:FBgn0025743 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_058592.1 Gene:Map3k14 / 53859 MGIID:1858204 Length:942 Species:Mus musculus


Alignment Length:563 Identity:147/563 - (26%)
Similarity:208/563 - (36%) Gaps:152/563 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 RSNSLRSSSPPRVRRVANVPPS------VPEEEGP--------------PAAGTPGVG----GAS 180
            ||.||..:.....:.:...|..      |.|:|.|              |..| ||:|    ...
Mouse   150 RSKSLAQAGVALAKPLPRTPEQESCTIPVQEDESPLGNLYARNVSQFTKPLGG-PGLGHLCFKKQ 213

  Fly   181 SGGFKPPGAHPSLLYNSQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSV 245
            ..|.:|....|.|         :....||........|..      |.:.|..|......|.   
Mouse   214 DEGLRPVLPRPEL---------HKLISPLQCLNHVWKLHH------PQATGPRPHPTHPFPY--- 260

  Fly   246 ASGTRSNHSHTNNGNSGGSYP-PMYPTSHQQQQQQQQQA--KQGGDQNQNPL--HPH----AH-- 299
                           ||..:| |.||....:........  |..|...|.||  .||    ||  
Mouse   261 ---------------SGMPHPFPFYPLEPWKPYMLDSAVLDKLAGVSGQRPLPGPPHLSQLAHGD 310

  Fly   300 -----PHPHHH--------------QHLAKSASRASSSSGGASSAAQQASGASGGAA-----GQP 340
                 |.||..              :.....|.:.|.|||.|.|.|..|...|.|:|     |..
Mouse   311 SQKPLPGPHLESSCPSRGALEKVPVEEYLVHALQGSVSSGQAHSLASLAKTWSSGSAKLQRLGPE 375

  Fly   341 KQDQR---LTHE------QFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAV 396
            .:|..   ||.:      ::|..:..          :.|..::|.||.|.|....||.||.|.||
Mouse   376 TEDNEGVLLTEKLKPVDYEYREEVHW----------MTHQPRVGRGSFGEVHRMKDKQTGFQCAV 430

  Fly   397 KKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWV--VMEYLEGGALTDIVTH-SR 458
            ||:.|...:..||     |.......|.||..|.:  |.:..||  .||.||||:|..::.. ..
Mouse   431 KKVRLEVFRVEEL-----VACAGLSSPRIVPLYGA--VREGPWVNIFMELLEGGSLGQLIKQMGC 488

  Fly   459 MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADG-RVKLSDFG--FCAQ---VSQELP 517
            :.|::......|.|:.|.|||::.::|.|:|:|::||::|| |..|.|||  .|.|   :.:.|.
Mouse   489 LPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLL 553

  Fly   518 KRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPP---FF---------NEPPLQA 570
            ....:.||...|:|||:...|...:|||||...|::.|::|..|   :|         :|||   
Mouse   554 TGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPP--- 615

  Fly   571 MRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAEL 613
              .||::.|       ..:|.....:...|.::|..||:|.||
Mouse   616 --PIREIPP-------SCAPLTAQAIQEGLRKEPVHRASAMEL 649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbtNP_523375.2 CRIB_PAK_like 9..54 CDD:238526
STKc_PAK_II 360..620 CDD:270815 87/275 (32%)
Map3k14NP_058592.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..156 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..326 10/34 (29%)
STKc_NIK 395..662 CDD:270893 88/284 (31%)
Interaction with ZFP91. /evidence=ECO:0000250 403..655 87/266 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..756
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..823
Blue background indicates that the domain is not in the aligned region.

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