Protein Alignment mbt and PAK3

DIOPT Version :9

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001121640.1
• Gene: PAK3 / 5063
• HGNCID: 8592
• Length: 580
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 221/646 - (34%)
• Similarity: 332/646 - (51%)
• Gaps: 149/646 - (23%)

  Fly     4 KKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTE 68
            |:|::|.||:||:|||.:|.|||....::...|.|             ::||:.:
Human    63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ-------------TSRPVTV---------- 104

  Fly    69 ILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPM--NPMAPGAHPMMSHGPGMMMPPETGGIV 131
                                    :|:...|.|..:  :.|.||..|     .|:   ||....:
Human   105 ------------------------ASSQSEGKMPDLYGSQMCPGKLP-----EGI---PEQWARL 137

  Fly   132 LPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYN 196
            | :||::.:..  :..:|..|..|..                                    .|:
Human   138 L-QTSNITKLE--QKKNPQAVLDVLK------------------------------------FYD 163

  Fly   197 SQHAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNH----SHTN 257
            |:               :..|.|:|.                     |..||.:|.|    :|.:
Human   164 SK---------------ETVNNQKYM---------------------SFTSGDKSAHGYIAAHPS 192

  Fly   258 NGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSA---SRASSSS 319
            :..: .|.||:.|...:::.:::::.:   |:|:.|  |...|.|.|.:.:...:   |.||.:.
Human   193 STKT-ASEPPLAPPVSEEEDEEEEEEE---DENEPP--PVIAPRPEHTKSIYTRSVVESIASPAV 251

  Fly   320 GGASSAAQQASGASGGA----AGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTG 380
            .........|..|:...    ..:.::..::|.|:....|:.:||.|||::....|.|||:|::|
Human   252 PNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASG 316

  Fly   381 TVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYL 445
            ||..|.|.:||::||:|:|:|::|.::||:.||:::||:..:||||....|:||.||||||||||
Human   317 TVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYL 381

  Fly   446 EGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCA 510
            .||:|||:||.:.|||.|||.||::||:||.:|||..|||||||||:|||..||.|||:||||||
Human   382 AGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 446

  Fly   511 QVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIR 575
            |::.|..||.::|||||||:|||::|..|||:|||||||||.||||:||||:.||.||:|:..|.
Human   447 QITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA 511

  Fly   576 DMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNAR 636
            ....|.|:|..::|...:.||:|.|..|..:|.:|.|||.||||:.|.|.|.|.||:..|:
Human   512 TNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAK 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	14/44 (32%)
		STKc_PAK_II	360..620	CDD:270815	148/259 (57%)
		S_TKc	372..619	CDD:214567	142/246 (58%)
PAK3	NP_001121640.1	PBD	69..162	CDD:307091	31/186 (17%)
		STKc_PAK3	284..580	CDD:132987	159/289 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D757766at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820