DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mbt and Mekk1

DIOPT Version :10

Sequence 1:NP_523375.2 Gene:mbt / 32631 FlyBaseID:FBgn0025743 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster


Alignment Length:391 Identity:106/391 - (27%)
Similarity:167/391 - (42%) Gaps:65/391 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   292 NPLHPHAHPHPH----HHQHLAK------SASRASSSSGGASSAAQQASG-------------AS 333
            ||..|.....|:    |.|...|      |.|...||....:...:.|:|             ||
  Fly  1156 NPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPAS 1220

  Fly   334 GGAAGQPKQDQRLTHEQFRAALQMV-------------------VSAGDP---RENLDHFN---- 372
            .|.:........|..|:.|.|:..:                   :::.|.   |....||.    
  Fly  1221 PGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRG 1285

  Fly   373 -KIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRREL--LFNEVVIMRDYHHPNIVETYSSFLV 434
             |||:|..|.|..|.:.:||..:|:|::.::..:.|.|  :..|:.|:....|.|:|..|...:.
  Fly  1286 IKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVH 1350

  Fly   435 NDELWVVMEYLEGGALTDIV-THSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAAD 498
            .:||.:.||....|.|..:| ....:.|........|.|..::.||..|::|||||:.:|.| .|
  Fly  1351 REELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VD 1414

  Fly   499 G--RVKLSDFGFCAQVSQE--LP-KRKSLVGTPYWMSPEVISRL---PYGPEVDIWSLGIMVIEM 555
            |  .:||.|||...::...  :| :.:..|||..:|:|||.::.   .:|...||||:|.:|:||
  Fly  1415 GSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEM 1479

  Fly   556 VDGEPPFFN-EPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFL 619
            ..|:.|:.. :...|.|.::...:.|....:  :|.....|:|..|..||.:|.||.|||.|.|.
  Fly  1480 ASGKRPWAQFDSNFQIMFKVGMGEKPQAPES--LSQEGHDFIDHCLQHDPKRRLTAVELLEHNFC 1542

  Fly   620 R 620
            :
  Fly  1543 K 1543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mbtNP_523375.2 CRIB_PAK_like 9..54 CDD:238526
STKc_PAK_II 360..620 CDD:270815 86/279 (31%)
Mekk1NP_732373.1 MEKK4_N 105..>930 CDD:466077
STKc_MEKK4 1281..1542 CDD:270796 81/263 (31%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.