DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and MAP3K3

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_976226.1	Gene:	MAP3K3 / 4215	HGNCID:	6855	Length:	657	Species:	Homo sapiens

Alignment Length:	675	Identity:	173/675 - (25%)
Similarity:	268/675 - (39%)	Gaps:	147/675 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPT 67
            :.:|||.|..:...|||.                       |..:|:..| ||:...|......|
Human    66 ASEKKKFLSDVRIKFEHN-----------------------GERRIIAFS-RPVKYEDVEHKVTT 106

  Fly    68 ---EILDLKTIVRPHHNNNKAD------------------TTSLNSSSTMMM------GSMAPMN 105
               :.|||      |:.||:..                  ::|:.|...:::      .|.:|.:
Human   107 VFGQPLDL------HYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHS 165

  Fly   106 PMAPGAHPMMSHGPG----MMMPPETGGIVLPKTSH--VARSNSLRSSSPPRVRRVANVPPSVPE 164
            .::.......|...|    :..|||      |::.|  |:..|..|||.||..         |||
Human   166 GVSRQVRIKASQSAGDINTIYQPPE------PRSRHLSVSSQNPGRSSPPPGY---------VPE 215

  Fly   165 EEGPPAAGTPGVGGASSGGFKPPGAHPSLL--YNSQHAHANGATGPLAVRTDQTNLQQYRSNLAP 227
            .:...|.........|.|.|.|..:...:|  .:|.....:|:...|....|..:.::.|.:.|.
Human   216 RQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSRMSRAQ 280

  Fly   228 PSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTS-HQQQQQQQQQAKQGGDQNQ 291
                |.|..:|       ....|....: :.|..||:||..|..| |.:.....::
Human   281 ----SFPDNRQ-------EYSDRETQLY-DKGVKGGTYPRRYHVSVHHKDYSDGRR--------- 324

  Fly   292 NPLHPHAHPHPHHHQ---HLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRA 353
                  ..|....||   .....:||:.|::|.....|.|.....|          ||.......
Human   325 ------TFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRG----------RLRSADSEN 373

  Fly   354 ALQMV---VSAGDPRE--NLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDL---RKQQRREL- 409
            ||.:.   |....|..  |......:|:|:.|.|.:..|..|||::|.|::..   ..:..:|:
Human   374 ALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVS 438

  Fly   410 -LFNEVVIMRDYHHPNIVETYSSFLVNDE--LWVVMEYLEGGALTD-IVTHSRMDEEQIATVCKQ 470
             |..|:.::::..|..||:.|.......|  |.:.|||:.||::.| :..:..:.|.......:|
Human   439 ALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQ 503

  Fly   471 CLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPK-------RKSLVGTPYW 528
            .|:.::||||..::|||||..:||..:.|.|||.|||    .|:.|..       .:|:.|||||
Human   504 ILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG----ASKRLQTICMSGTGMRSVTGTPYW 564

  Fly   529 MSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQ 593
            |||||||...||.:.|:||||..|:||:..:||:.....:.|:.:|. .||.|.:....:|...:
Human   565 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA-TQPTNPQLPSHISEHGR 628

  Fly   594 SFLDRMLVRDPAQRATAAELLAHPF 618
            .||.|:.| :..||.:|.|||.|.|
Human   629 DFLRRIFV-EARQRPSAEELLTHHF 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	7/44 (16%)
		STKc_PAK_II	360..620	CDD:270815	93/276 (34%)
		S_TKc	372..619	CDD:214567	91/262 (35%)
MAP3K3	NP_976226.1	PB1_Mekk2_3	76..154	CDD:99726	18/107 (17%)
MAP3K3	NP_976226.1	STKc_MEKK3_like	392..652	CDD:270795	91/265 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910