DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and pak5

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_998127.1	Gene:	pak5 / 405898	ZFINID:	ZDB-GENE-040426-2085	Length:	711	Species:	Danio rerio

Alignment Length:	785	Identity:	345/785 - (43%)
Similarity:	419/785 - (53%)	Gaps:	225/785 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.||||:..||.||||||||||.||.::.|:.|||.||.|::.:     ::|||.|:||||.||
Zfish     1 MFGKKKKRLEISAPSNFEHRVHTDFDPQQQKFTGLPQQWQSLLAD-----TANRPKPMVDPSYIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130
            |.::..:|||||                     ||.||.:....|            :..|...|
Zfish    61 PIQLAPMKTIVR---------------------GSRAPRDASING------------LLEEFDSI 92

  Fly   131 VLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPG------- 188
                  .|:||||||..|                    |||.....|..:..||...|
Zfish    93 ------SVSRSNSLRRES--------------------PAAAAAAAGSRAQNGFGQYGRYSCDLD 131

  Fly   189 -----------------AHPSL-----------------------LYNSQHAHANGAT-----GP 208
                             .||.|                       |....||:....|     ||
Zfish   132 SGVCVEAEWQRSSLRQNGHPGLGPGPIRSPFYPDAMPQKASEWARLPPDYHAYLESRTQLCGEGP 196

  Fly   209 ---------------------------LAVRTDQTNL---------------QQYRSNLAPPSGG 231
                                       |::|:|.|:.               ..|.|:     |.
Zfish   197 VGRRDYRASLGGSSLDYRDAPLGTPSRLSLRSDHTSCPDADWGFGELHKRPKSSYGSH-----GS 256

  Fly   232 SMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSY--------PPM-------YPTSHQQ------ 275
            ..|..:|.|     .||:......:::|:||..|        ||.       ||...:.
Zfish   257 PQPALRQRS-----RSGSGLQEPSSSSGSSGAPYSISALSAAPPQGSYSSYTYPRLSENTSAMII 316

  Fly   276 -QQQQQQQAKQGGDQ------NQNPLH-PHA---------------HPHPHHHQHLAKS------ 311
             :.:.::..:.|..|      .:.||. ||:               .|.|:.|.....|
Zfish   317 GKAEYERVCRDGSPQAVCEPYPRVPLKLPHSKALYPPVLQYPPLLCQPSPYQHPPSQPSPPYTPA 381

  Fly   312 ASRASSSSGGASSAAQQASGAS-----GGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHF 371
            .:.|.|.:....|:.....||.     |..|.||  ..|::|||||||||:||..||||:.||.|
Zfish   382 GAHAHSHTHSQPSSPYVPPGAYPPPSWGSPAEQP--PPRVSHEQFRAALQLVVEPGDPRQGLDSF 444

  Fly   372 NKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVND 436
            .||||||||.|||||:|.:|:||||||||||||||||||||||||||||||.|:|:.|:|:||.|
Zfish   445 LKIGEGSTGIVCIATEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNSYLVGD 509

  Fly   437 ELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRV 501
            |||||||:||||||||||||:||:||||||||...||||:|||:|||||||||||||||.:|||:
Zfish   510 ELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHTQGVIHRDIKSDSILLTSDGRI 574

  Fly   502 KLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEP 566
            ||||||||||||:|:|||||||||||||:||||||||||.||||||||||||||||||||:||||
Zfish   575 KLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEP 639

  Fly   567 PLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPL 631
            ||||||||||..||.||.:||||..|::|||.||||:|:|||:|.|||.:|||:.||||:.:|||
Zfish   640 PLQAMRRIRDNLPPRLKESHKVSSVLRAFLDLMLVREPSQRASALELLQNPFLKLAGPPACIVPL 704

  Fly   632 MRNAR 636
            ||:.|
Zfish   705 MRHYR 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	21/44 (48%)
		STKc_PAK_II	360..620	CDD:270815	209/259 (81%)
		S_TKc	372..619	CDD:214567	201/246 (82%)
pak5	NP_998127.1	CRIB_PAK_like	9..55	CDD:238526	25/50 (50%)
		STKc_PAK5	418..709	CDD:132989	231/290 (80%)
		S_TKc	446..692	CDD:214567	201/245 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I622
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131221at33208
OrthoFinder	1	1.000	-	-		FOG0001853
OrthoInspector	1	1.000	-	-		otm26512
orthoMCL	1	0.900	-	-		OOG6_105633
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820