DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and Slik

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_726441.1	Gene:	Slik / 37893	FlyBaseID:	FBgn0035001	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	100/266 - (37%)
Similarity:	151/266 - (56%)	Gaps:	7/266 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 DPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVE 427
            ||.|..:...::|:|:.|.|..|..|...|..|.|...|..::.......|:.|:.:..||||||
  Fly    32 DPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVE 96

  Fly   428 TYSSFLVNDELWVVMEYLEGGALTDIVT--HSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKS 490
            .|.:|.::|:||:::||.:||||..|:.  ...:.|.|||.|||...:.|.:||...|||||:|:
  Fly    97 LYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKA 161

  Fly   491 DSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVI-----SRLPYGPEVDIWSLGI 550
            .::||..:|.|||:|||..|:....:.|..:.:||||||:||::     ...||..:||||||||
  Fly   162 GNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGI 226

  Fly   551 MVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLA 615
            .:||:...|||.....|::.:.:|:..:||.|:...:.|.....||.:.||:||..|.|...|:.
  Fly   227 TLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQ 291

  Fly   616 HPFLRQ 621
            |.|:.:
  Fly   292 HAFINR 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	100/263 (38%)
		S_TKc	372..619	CDD:214567	96/253 (38%)
Slik	NP_726441.1	STKc_SLK_like	31..310	CDD:132942	100/266 (38%)
		S_TKc	37..295	CDD:214567	96/257 (37%)
		PKK	958..1095	CDD:289257
		PKK	1126..1266	CDD:289257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840