DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and map4k5

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_021336201.1	Gene:	map4k5 / 334565	ZFINID:	ZDB-GENE-030131-6497	Length:	894	Species:	Danio rerio

Alignment Length:	287	Identity:	109/287 - (37%)
Similarity:	169/287 - (58%)	Gaps:	12/287 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 DPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVE 427
            :|:.:.:...::|.|:.|.|..|...|||...|||.:.|.......::..|:.::::..|.|||.
Zfish    15 NPQHDFELIQRVGSGTYGDVYKARKISTGELAAVKIIKLEPGDDFSIIQQEIFMVKECTHHNIVA 79

  Fly   428 TYSSFLVNDELWVVMEYLEGGALTDI--VTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKS 490
            .:.|:|..::||:.|||..||:|.||  || ..:.|.|||.||::.|:.|.||||:|.:|||||.
Zfish    80 YFGSYLCREKLWICMEYCGGGSLQDIYHVT-GPLSELQIAYVCRETLQGLGYLHSKGKMHRDIKG 143

  Fly   491 DSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS---RLPYGPEVDIWSLGIMV 552
            .:|||..:|.|||:|||..|:::..:.||||.:||||||:|||.:   ...|....|||::||..
Zfish   144 ANILLTDNGDVKLADFGVAAKITATMAKRKSFIGTPYWMAPEVAAVEKNGGYNHLCDIWAVGITS 208

  Fly   553 IEMVDGEPPFFNEPPLQAMRRI--RDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLA 615
            ||:.:.:||.|:..|::|:..:  .:.|||.||:..|.|....:|:...|.::|.:|.||.::|:
Zfish   209 IELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSTAFHNFVKLSLTKNPKRRPTAEKMLS 273

  Fly   616 HPFLRQAGPPSL----LVPLMRNARHH 638
            |.|:.|.|....    |:..|.|..:|
Zfish   274 HLFVGQTGLTRRLALELLDKMNNPDNH 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	103/263 (39%)
		S_TKc	372..619	CDD:214567	101/253 (40%)
map4k5	XP_021336201.1	STKc_MAP4K5	10..277	CDD:270813	102/262 (39%)
map4k5	XP_021336201.1	CNH	559..874	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910