DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and stk3

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_955966.1	Gene:	stk3 / 324125	ZFINID:	ZDB-GENE-030131-2845	Length:	492	Species:	Danio rerio

Alignment Length:	274	Identity:	112/274 - (40%)
Similarity:	166/274 - (60%)	Gaps:	4/274 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 PRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVET 428
            |.|..|...|:||||.|:|..|..|.:|:.||:|::.:....:.  :..|:.||:....|.:|:.
Zfish    22 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSPYVVKY 84

  Fly   429 YSSFLVNDELWVVMEYLEGGALTDIV--THSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSD 491
            |.|:..|.:||:||||...|:::||:  .:..:.|::||||.|..||.|.|||....||||||:.
Zfish    85 YGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATVLKSTLKGLEYLHFMRKIHRDIKAG 149

  Fly   492 SILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMV 556
            :|||..:|..||:|||...|::..:.||.:::|||:||:||||..:.|....|||||||..|||.
Zfish   150 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMA 214

  Fly   557 DGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQ 621
            :|:||:.:..|::|:..|....||..:.....|.....|:.:.||::|.|||||.:||.|||:..
Zfish   215 EGKPPYADIHPMRAIFMIPTNPPPTFRKPEHWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIVG 279

  Fly   622 AGPPSLLVPLMRNA 635
            |.|.|:|..|:..|
Zfish   280 AKPVSILRDLITEA 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	106/257 (41%)
		S_TKc	372..619	CDD:214567	102/248 (41%)
stk3	NP_955966.1	STKc_MST1_2	22..277	CDD:132943	105/256 (41%)
		S_TKc	26..277	CDD:214567	103/252 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..339
		Mst1_SARAH	438..485	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910