Protein Alignment mbt and Map3k3

DIOPT Version :9

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_001100528.1
• Gene: Map3k3 / 303604
• RGDID: 1304575
• Length: 626
• Species: Rattus norvegicus
• Alignment Length: 673
• Identity: 173/673 - (25%)
• Similarity: 274/673 - (40%)
• Gaps: 125/673 - (18%)

  Fly     8 KPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASI------VGNNQILKSSNRPLPLVDPSEITP 66
            |.|:::..:...|| :|::..:||..|.|.:.:.:      .|..:|:..| ||:...|......
  Rat    12 KDLVALQMSRRPRV-SGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFS-RPVRYEDVEHKVT 74

  Fly    67 T---EILDLKTIVRPHHNNNKAD------------------TTSLNSSSTMMMG------SMAPM 104
            |   :.|||      |:.||:..                  :.|:.|...:::.      |.:|.
  Rat    75 TVFGQPLDL------HYMNNELSILLKNQDDLDKAIDILDRSASMKSLRILLLSQDRNHTSSSPH 133

  Fly   105 NPMAPGAHPMMSHGPG----MMMPPETGGIVLPKTSH--VARSNSLRSSSPPRVRRVANVPPSVP 163
            :.::.......|...|    :...||      |::.|  |:..|..|||.||..         ||
  Rat   134 SGVSRQVRVKPSQSAGDINTIYQAPE------PRSRHLSVSSQNPGRSSPPPGY---------VP 183

  Fly   164 EEEGPPAAGTPGVGGASSGGFKPPGAHPSLL--YNSQHAHANGATGPLAVRTDQTNLQQYRSNLA 226
            |.:...|.........|.|.|.|..:...:|  .:|.....:|:...|.           ||..:
  Rat   184 ERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLD-----------RSADS 237

  Fly   227 PPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTS-HQQQQQQQQQAKQGGDQN 290
            |....|...:.::.|........|....: :.|..||:||..|..| |.:            |.|
  Rat   238 PSFRKSQMSRARSFPDNRKECSDRETQLY-DKGVKGGTYPRRYHVSVHHK------------DYN 289

  Fly   291 QNPLHPHAHPHPHHHQ---HLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFR 352
            ..   ....|....||   .....:||:.|::|....||.|.....|.......::.....|:
  Rat   290 DG---RRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGAAVQYLDPRGRLRSADSENALTVQER-- 349

  Fly   353 AALQMVVSAGDPRE--NLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDL---RKQQRREL--L 410
                 .|....|..  |......:|:|:.|.|.:..|..|||::|.|::..   ..:..:|:  |
  Rat   350 -----SVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSAL 409

  Fly   411 FNEVVIMRDYHHPNIVETYSSFLVNDE--LWVVMEYLEGGALTD-IVTHSRMDEEQIATVCKQCL 472
            ..|:.::::..|..||:.|.......|  |.:.|||:.||::.| :..:..:.|.......:|.|
  Rat   410 ECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL 474

  Fly   473 KALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPK-------RKSLVGTPYWMS 530
            :.::||||..::|||||..:||..:.|.|||.|||    .|:.|..       .:|:.|||||||
  Rat   475 EGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFG----ASKRLQTICMSGTGMRSVTGTPYWMS 535

  Fly   531 PEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSF 595
            |||||...||.:.|:||||..|:||:..:||:.....:.|:.:|. .||.|.:....:|...:.|
  Rat   536 PEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA-TQPTNPQLPSHISEHGRDF 599

  Fly   596 LDRMLVRDPAQRATAAELLAHPF 618
            |.|:.| :..||.:|.|||.|.|
  Rat   600 LRRIFV-EARQRPSAEELLTHHF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	11/50 (22%)
		STKc_PAK_II	360..620	CDD:270815	93/276 (34%)
		S_TKc	372..619	CDD:214567	91/262 (35%)
Map3k3	NP_001100528.1	PB1_Mekk2_3	45..123	CDD:99726	15/84 (18%)
		STKc_MEKK3_like	361..621	CDD:270795	91/265 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910