DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and Map4k2

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_006230815.1	Gene:	Map4k2 / 293694	RGDID:	1308199	Length:	821	Species:	Rattus norvegicus

Alignment Length:	289	Identity:	116/289 - (40%)
Similarity:	169/289 - (58%)	Gaps:	8/289 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 ALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMR 418
            ||...||..|||:..:...::|.|:.|.|..|.|..|....|||.:.|........|..|:.|:|
  Rat     2 ALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILR 66

  Fly   419 DYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR--MDEEQIATVCKQCLKALAYLHSQ 481
            :..|||:|....|:|.||.||:.||:..||:|.:|. |:.  ::|.|||.||::.||.|.:||||
  Rat    67 ECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIY-HATGPLEERQIAYVCREALKGLHHLHSQ 130

  Fly   482 GVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS---RLPYGPEV 543
            |.||||||..::||...|.|||:|||...:::..:.||:|.:||||||:|||.:   :..|....
  Rat   131 GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELC 195

  Fly   544 DIWSLGIMVIEMVDGEPPFFNEPPLQAMRRI--RDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQ 606
            |:|:|||..||:.:.:||.|:..|::|:..:  ...|||.|::..:.:.....||...|.::|.:
  Rat   196 DVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQTFHHFLKLALTKNPKK 260

  Fly   607 RATAAELLAHPFLRQAGPPSLLVPLMRNA 635
            |.||.:||.|||..|..||:||..|:..|
  Rat   261 RPTAEKLLQHPFTTQPLPPALLTQLLDKA 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	106/266 (40%)
		S_TKc	372..619	CDD:214567	101/253 (40%)
Map4k2	XP_006230815.1	STKc_MAP4K3_like	16..272	CDD:270788	100/256 (39%)
		S_TKc	16..272	CDD:214567	100/256 (39%)
		CNH	489..801	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000