Protein Alignment mbt and shk1

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_596626.1
• Gene: shk1 / 2539997
• PomBaseID: SPBC1604.14C
• Length: 658
• Species: Schizosaccharomyces pombe
• Alignment Length: 639
• Identity: 196/639 - (30%)
• Similarity: 303/639 - (47%)
• Gaps: 132/639 - (20%)

  Fly     6 KKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTEIL 70
            :|..:||.|.:.:|..|.||:....::.|:|.:|.:::..:.|.||.
pombe   142 RKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSE------------------ 188

  Fly    71 DLKTIVRPHHNNNKADTTSLNSSSTMMM--GSMAPMNPMAPGAHPMMSHGPGMMMPPETGGIVLP 133
                  :..|.....|..:..|.|...:  |:..|. |......|::|..            .|.
pombe   189 ------QVQHPQAVLDAMAFYSQSKKYLEEGAKPPF-PRESTEKPLLSVS------------ALS 234

  Fly   134 KTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYNSQ 198
            .:||:..:::..|||        .:.||.|       |.||           |..:..|.|.:||
pombe   235 SSSHLQPTSATSSSS--------RLYPSRP-------APTP-----------PASSSSSPLLSSQ 273

  Fly   199 HAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGG 263
                       .|:|..:|                 ..:|.||:.|..|......||:
pombe   274 -----------TVKTTTSN-----------------ASRQPSPLVSSKSTDNIIRSHS------- 303

  Fly   264 SYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSASRASSSSGGASSAAQQ 328
                  |.....|.....:.|.....|..|           :|..|:::::..     |.:..|:
pombe   304 ------PVLLTPQTLSTSETKHIRPNNSTP-----------YQRRAETSTKPK-----AVATPQK 346

  Fly   329 ASGASGGAAGQPKQDQRLTHEQFR-----AALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDK 388
            ....|.     |:..:|...:|..     |.||.:.:..:|.....:|.|||:|::|.|..|...
pombe   347 VEAPSA-----PRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQV 406

  Fly   389 STGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDI 453
            .|...||:|||::.:|.::|.:.||:::|:.:||.|||....:|....|||:||||:.||:||::
pombe   407 GTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEV 471

  Fly   454 VTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPK 518
            ||::.:.|.|||.:||:.|:.|.:||..|::|||||||:|||:..|.:||:|||||||:...:.|
pombe   472 VTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTK 536

  Fly   519 RKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLK 583
            |.::|||||||:|||::|..||.:||:||||||.||||:||||:.||.||:|:..|..:..|.:.
pombe   537 RTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKIS 601

  Fly   584 NAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNARH 637
            ....:|.....||.:.|..:|.||.::.|||.||||:||.|.|.|:||:::..|
pombe   602 RPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHH 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	13/44 (30%)
		STKc_PAK_II	360..620	CDD:270815	121/259 (47%)
shk1	NP_596626.1	PBD	147..204	CDD:395634	15/80 (19%)
		STKc_PAK	385..638	CDD:270789	120/252 (48%)