DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mbt and Pak5

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_006499571.1	Gene:	Pak5 / 241656	MGIID:	1920334	Length:	736	Species:	Mus musculus

Alignment Length:	791	Identity:	357/791 - (45%)
Similarity:	426/791 - (53%)	Gaps:	225/791 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.|||||..||.|||||||||||||.:|.|:.|||.||.|::.:     ::|||.|:||||.||
Mouse    18 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLAD-----TANRPKPMVDPSCIT 77

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130
            |.::..:|||||   .|.....||:|       |.:...:.::
Mouse    78 PIQLAPMKTIVR---GNKSCKETSIN-------GLLEDFDNIS---------------------- 110

  Fly   131 VLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGAS-------SGGFKPPG 188
                   |.||||||..|||                      ||..|.||       ..||....
Mouse   111 -------VTRSNSLRKESPP----------------------TPDQGAASRIQGHSEENGFITFS 146

  Fly   189 AHPS------------------------LLYNSQH-AHANGATGPL-----------AVRTD--- 214
            .:.|                        |.|.|.| |..||....:           :::||
Mouse   147 QYSSESDTTADYTTEKYRDRSLYGDDLDLYYKSSHAAKQNGHAMKMKHGDAYYPEMKSLKTDLAG 211

  Fly   215 -----QTNLQQYR---------------SNLAP--------PS--------------------GG 231
                 .|:|...|               |:.:|        ||                    |.
Mouse   212 FPVDYHTHLDSLRKSSEYGDLRWDYQRASSSSPLDYSFQLTPSRTAGTSRCSKESLAYSESDWGP 276

  Fly   232 SM------------------PQQQQTSPVGS------VASGTRSNHSHTNNGNSGGSY------- 265
            |:                  |..:|.|..||      :..|..:..:|. .|:|..||
Mouse   277 SLDDYDRRPKSSYLHQTSPQPAMRQRSKSGSGLQEPMMPFGASAFKTHP-QGHSYNSYTYPRLSE 340

  Fly   266 ------------------PPM-----YPTSHQQQQQQQQQAKQGGDQNQNPLHPHA-----HPHP 302
                              ||:     ||....:..|.|.:|......:|.|...|.     ||..
Mouse   341 PTMCIPKVDYDRAQMVFSPPLSGSDTYPRGPTKLPQSQSKAGYSSGSHQYPSGYHKASLYHHPSL 405

  Fly   303 HHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPREN 367
            ........:||..||.|..:|:....:.|:|     ..:|..|::|||||||||:|||.|||||.
Mouse   406 QTSSQYISTASYLSSLSISSSTYPPPSWGSS-----SDQQPSRVSHEQFRAALQLVVSPGDPREY 465

  Fly   368 LDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSF 432
            ||:|.||||||||.|||||:|.||:||||||||||||||||||||||||||||||.|:|:.|:|:
Mouse   466 LDNFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNSY 530

  Fly   433 LVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAA 497
            ||.||||||||:||||||||||||:||:||||||||...||||:|||:|||||||||||||||.:
Mouse   531 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKSDSILLTS 595

  Fly   498 DGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPF 562
            |||:||||||||||||:|:|||||||||||||:||||||||||.||||||||||||||:|||||:
Mouse   596 DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPY 660

  Fly   563 FNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSL 627
            ||||||||||||||..||.:|:.||||..|:.|||.||||:|:|||||.|||.||||:.|||||.
Mouse   661 FNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSC 725

  Fly   628 LVPLMRNARHH 638
            :|||||..|||
Mouse   726 IVPLMRQYRHH 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	23/44 (52%)
		STKc_PAK_II	360..620	CDD:270815	212/259 (82%)
		S_TKc	372..619	CDD:214567	202/246 (82%)
Pak5	XP_006499571.1	CRIB_PAK_like	26..72	CDD:238526	27/50 (54%)
Pak5	XP_006499571.1	STKc_PAK5	443..734	CDD:132989	235/290 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I622
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	601	1.000	Inparanoid score	I942
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001853
OrthoInspector	1	1.000	-	-		otm43475
orthoMCL	1	0.900	-	-		OOG6_105633
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3286
SonicParanoid	1	1.000	-	-		X1054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850