Protein Alignment mbt and MAP3K8

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_005195.2
• Gene: MAP3K8 / 1326
• HGNCID: 6860
• Length: 467
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 96/308 - (31%)
• Similarity: 146/308 - (47%)
• Gaps: 36/308 - (11%)

  Fly   338 GQPKQDQRLTHEQFRAALQMVVSAGDPRENLDH----------FNKIG-----EGSTGTVCIATD 387
            ||..|:..:       .|.||::..:.|..:|.          :..||     .|:.|.|.:|.|
Human   100 GQRPQESGI-------LLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQD 157

  Fly   388 KSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGA-LT 451
            ..|.:::|.|.:.:.:.:.     ::|.|...:.|.||.|.|.:.|..:.:.:.||..|||: |.
Human   158 IKTKKRMACKLIPVDQFKP-----SDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLE 217

  Fly   452 DIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQEL 516
            .:.:...|.|.:|..|.|..||.|.:|||:.|||.|||..:|:..:...| |.|||...|:::::
Human   218 KLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDV 281

  Fly   517 PKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQA----MRRIRDM 577
            ...|.|.||..:||||||....:..:.||:|||..:|.|..|.||:....|..|    :..|...
Human   282 YFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQ 346

  Fly   578 QPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPP 625
            .||....|...||.::..::..|.|:|..|..||:||.|..|   .||
Human   347 APPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEAL---NPP 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	87/279 (31%)
MAP3K8	NP_005195.2	STKc_MAP3K8	133..388	CDD:270897	85/260 (33%)