DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and BUB1B-PAK6

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001122100.1	Gene:	BUB1B-PAK6 / 106821730	HGNCID:	52276	Length:	681	Species:	Homo sapiens

Alignment Length:	736	Identity:	322/736 - (43%)
Similarity:	401/736 - (54%)	Gaps:	167/736 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSKKKKK-PLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEI 64
            ||.||||| |.||.|.||:|||||.||.:|.|:||||.||      ..||.:..||.|:||||.|
Human     1 MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQW------QNILDTLRRPKPVVDPSRI 59

  Fly    65 TPTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGG 129
            |..::..:||:||                     ||..|::....|   :::.
Human    60 TRVQLQPMKTVVR---------------------GSAMPVDGYISG---LLND------------ 88

  Fly   130 IVLPKTSHVARSNSLRSSSPPRVRRVANV------------------PPSV-------------- 162
              :.|.| |..||:||..||...||..::                  |.|.
Human    89 --IQKLS-VISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGG 150

  Fly   163 ----------PEEEGPP------AAGTPGVGGASSGG-------------FKPPGAHP------- 191
                      ||.:.|.      ||....:|.|...|             ..||||.|
Human   151 TPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRH 215

  Fly   192 ---SLLYNSQHAHAN-----------GATGPLAVRTDQTNLQQ--YRSNL------APPSG---G 231
               :..:.|:.|...           |..|..:.:|.:::|::  :||..      ||||.   |
Human   216 GMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPG 280

  Fly   232 SMPQQ---------QQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGG 287
            ..||.         |:.:|...||..     ....:....|::.|: .||.....|:..:.....
Human   281 PPPQSKPNSSFRPPQKDNPPSLVAKA-----QSLPSDQPVGTFSPL-TTSDTSSPQKSLRTAPAT 339

  Fly   288 DQNQNPLHPHAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFR 352
            .|......|...|...|.|        .|:|:   ....|..:.|.|..||:  ....:|||||:
Human   340 GQLPGRSSPAGSPRTWHAQ--------ISTSN---LYLPQDPTVAKGALAGE--DTGVVTHEQFK 391

  Fly   353 AALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIM 417
            |||:|||..||||..||.:.||||||||.||:|.:|.:|||||||.|||||||||||||||||||
Human   392 AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIM 456

  Fly   418 RDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQG 482
            |||.|.|:||.|.|:||.:||||:||:|:||||||||:..|::||||||||:..|:||||||:||
Human   457 RDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQG 521

  Fly   483 VIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWS 547
            |||||||||||||..||||||||||||||:|:::|||||||||||||:||||||..|..||||||
Human   522 VIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWS 586

  Fly   548 LGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAE 612
            ||||||||||||||:|::.|:|||:|:||..||.|||:|||||.|:.||:|||||||.:||||.|
Human   587 LGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQE 651

  Fly   613 LLAHPFLRQAGPPSLLVPLMR 633
            ||.||||.|.|.|..||||::
Human   652 LLDHPFLLQTGLPECLVPLIQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	23/44 (52%)
		STKc_PAK_II	360..620	CDD:270815	194/259 (75%)
		S_TKc	372..619	CDD:214567	187/246 (76%)
BUB1B-PAK6	NP_001122100.1	PBD	11..67	CDD:307091	31/61 (51%)
BUB1B-PAK6	NP_001122100.1	STKc_PAK6	385..681	CDD:270821	213/288 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10865
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131221at33208
OrthoFinder	1	1.000	-	-		FOG0001853
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.880