Protein Alignment mbt and pak3

DIOPT Version :10

• Sequence 1: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: XP_004916907.1
• Gene: pak3 / 100495025
• XenbaseID: XB-GENE-961764
• Length: 556
• Species: Xenopus tropicalis
• Alignment Length: 633
• Identity: 221/633 - (34%)
• Similarity: 314/633 - (49%)
• Gaps: 147/633 - (23%)

  Fly     4 KKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEITPTE 68
            |:|::|.||:||:|||.:|.|||....::.|:|.|||.::..:.|.|...:.         .|..
 Frog    63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKK---------NPQA 118

  Fly    69 ILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGIVLP 133
            :||:..........|.....|..|......|.:|        ||.:.
 Frog   119 VLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIA--------AHSLF------------------ 157

  Fly   134 KTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLYNSQ 198
             .|||.: |:..:|.||       :.|.|.|||...                          ..:
 Frog   158 -LSHVLQ-NAKTASEPP-------LAPPVSEEEDEE--------------------------EEE 187

  Fly   199 HAHANGATGPLAVRTDQTNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGG 263
            ....|.....:|.|.:.|.....||.:.|.:..:..::..||||          .....|.||..
 Frog   188 EEDDNEPPPVIAPRPEHTKSIYTRSVIEPVALTAPAKEASTSPV----------TPQPENSNSST 242

  Fly   264 SYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQHLAKSASRASSSSGGASSAAQQ 328
            |      |.::...:|::::|
 Frog   243 S------TLYRNTDRQRKKSK-------------------------------------------- 257

  Fly   329 ASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQ 393
                             :|.|:....|:.:||.|||::....|.|||:|::|||..|.|.:||::
 Frog   258 -----------------MTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAIDIATGQE 305

  Fly   394 VAVKKMDLRKQQRRELLFNEVVIMRDYHHPNIVETYSSFLVNDELWVVMEYLEGGALTDIVTHSR 458
            ||:|:|:|::|.::||:.||:::||:..:||||....|:||.||||||||||.||:|||:||.:.
 Frog   306 VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC 370

  Fly   459 MDEEQIATVCKQCLKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLV 523
            |||.|||.||::||:||.:|||..|||||||||:|||..||.|||:|||||||::.|..||.::|
 Frog   371 MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV 435

  Fly   524 GTPYWMSPEVISRLPYGPEVDIWSLGIMVIEMVDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKV 588
            ||||||:|||::|..|||:|||||||||.||||:||||:.||.||:|:..|.....|.|:|..::
 Frog   436 GTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERL 500

  Fly   589 SPRLQSFLDRMLVRDPAQRATAAELLAHPFLRQAGPPSLLVPLMRNAR 636
            |...:.||:|.|..|..:|.:|.|||.||||:.|.|.|.|.||:..|:
 Frog   501 SAIFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLIIAAK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	19/44 (43%)
		STKc_PAK_II	360..620	CDD:270815	148/259 (57%)
pak3	XP_004916907.1	PBD	69..126	CDD:395634	21/65 (32%)
		STKc_PAK3	260..556	CDD:132987	159/289 (55%)