DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and pak5

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001120110.1	Gene:	pak5 / 100145129	XenbaseID:	XB-GENE-960008	Length:	349	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	103/365 - (28%)
Similarity:	135/365 - (36%)	Gaps:	120/365 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65
            ||.|||||..||.|||||||||||||.:|.|::|||.||.|::.:     ::|||.|:||||.||
Frog     1 MFGKKKKKLDISGPSNFEHRVHTGFDHKEQKFIGLPQQWQSLLAD-----TANRPKPMVDPSCIT 60

  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130
            |.::..:|||||                     ||..|.:....|            :..:...|
Frog    61 PIQLAPMKTIVR---------------------GSKPPQDTYING------------LLEDFDNI 92

  Fly   131 VLPKTSHVARSNSLRSSSPPRVR-RVANVPPSVPEEEG---------PPAAGTPGVG-------- 177
                  .|.||||||..|||..| ..:|.....|||.|         .|......:.
Frog    93 ------SVTRSNSLRKESPPTPRLGHSNHLKGYPEENGFFAFSQYSCEPEVQRSNISERYKERSL 151

  Fly   178 GASSG-----GFKP--PGAHPSLL-------------------YNSQHAHANGATGPLAVRTDQ- 215
            .|...     ..||  ...||..:                   |.|:: |....|...:|  ||
Frog   152 SAEEAEVYYRANKPVRHNGHPVKMRSYETYFPEVKSVRADLSSYPSEY-HPQLETKSKSV--DQY 213

  Fly   216 -------TNLQQYRSNLAPPSGGSMPQQQQTSPVGSVASGTRSNHSHTNNGNSGGSYPPMYPTSH 273
                   |:||.||....|...|::        :.|..|..|..:|....|.....|.....:|:
Frog   214 DYHSIAGTSLQDYRDYFPPSITGTI--------MLSEGSRERLEYSEWGEGLPKDDYDKRPKSSY 270

  Fly   274 QQQ---QQQQQQAKQGGDQNQNPLHPH----------AHP 300
            ..|   |...:|..:.|...|.|:.|:          .||
Frog   271 ITQTSPQPAMRQRSRSGSGLQEPIIPYGAGVMKTNQQGHP 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	23/44 (52%)
		STKc_PAK_II	360..620	CDD:270815
		S_TKc	372..619	CDD:214567
pak5	NP_001120110.1	CRIB_PAK_like	11..55	CDD:238526	27/48 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I636
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	595	1.000	Inparanoid score	I959
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131221at33208
OrthoFinder	1	1.000	-	-		FOG0001853
OrthoInspector	1	1.000	-	-		otm48630
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3286
SonicParanoid	1	1.000	-	-		X1054
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090