DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mbt and map4k3b

DIOPT Version :9

Sequence 1:	NP_523375.2	Gene:	mbt / 32631	FlyBaseID:	FBgn0025743	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_009291338.1	Gene:	map4k3b / 100005183	ZFINID:	ZDB-GENE-090428-1	Length:	897	Species:	Danio rerio

Alignment Length:	290	Identity:	117/290 - (40%)
Similarity:	176/290 - (60%)	Gaps:	8/290 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 LQMVVSAGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRD 419
            |.:.:|..:|:|:.:...:||.|:.|.|..|.:.|||...|:|.:.|...:..:::..|:::|:|
Zfish     3 LSLDLSRRNPQEDFELIQRIGSGTYGDVYKARNVSTGELAAIKVIKLEPGEDFDVVQQEIIMMKD 67

  Fly   420 YHHPNIVETYSSFLVNDELWVVMEYLEGGALTDI--VTHSRMDEEQIATVCKQCLKALAYLHSQG 482
            ..|.|||..:.|:|..|:||:.|||..||:|.||  || ..:.|.|||.||::.|:.:.|||::|
Zfish    68 CKHSNIVAYFGSYLRRDKLWISMEYCGGGSLQDIYHVT-GPLSESQIAYVCRETLQGVYYLHNKG 131

  Fly   483 VIHRDIKSDSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVIS---RLPYGPEVD 544
            .||||||..:|||..:|.|||:|||..||:|..|.||||.:||||||:|||.:   :..|....|
Zfish   132 KIHRDIKGANILLTDNGYVKLADFGVSAQISATLAKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 196

  Fly   545 IWSLGIMVIEMVDGEPPFFNEPPLQAMRRI--RDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQR 607
            ||::||..||:.:.|||.|:..|::|:..:  ...|||.||:..|.:.....|:...|.::|.:|
Zfish   197 IWAVGITAIELAELEPPMFDLHPMRALFLMTKSSFQPPKLKDKVKWTNNFHHFVKMALTKNPKKR 261

  Fly   608 ATAAELLAHPFLRQAGPPSLLVPLMRNARH 637
            .||..||.|||:.|....:|.:.|:..|.:
Zfish   262 PTADRLLQHPFVTQPLSRTLAIELLDKANN 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526
		STKc_PAK_II	360..620	CDD:270815	112/266 (42%)
		S_TKc	372..619	CDD:214567	108/253 (43%)
map4k3b	XP_009291338.1	STKc_MAP4K3	4..275	CDD:270812	112/271 (41%)
map4k3b	XP_009291338.1	CNH	564..877	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910