DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and NUP153

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_001265138.1	Gene:	NUP153 / 9972	HGNCID:	8062	Length:	1506	Species:	Homo sapiens

Alignment Length:	1828	Identity:	468/1828 - (25%)
Similarity:	713/1828 - (39%)	Gaps:	518/1828 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 GSQRQRE----PAYNFFTGNEAAEGSTGDLPHSIRRSLNIPFG-------------GSSTATSYN 326
            |..|.|.    |...:..|.:..:|....:..|::   ||..|             ..||.||
Human    14 GKIRTRRCHQGPIKPYQQGRQQHQGILSRVTESVK---NIVPGWLQRYFNKNEDVCSCSTDTS-- 73

  Fly   327 NSLSSLPNHKRPSLIGKQTHRRDLTMDETGTGPAMSSEEHLNHLLRISRTNNNTSN--------N 383
             .:...|.:|...|:.......::|.......||:|:.|.       ..|.:..||        :
Human    74 -EVPRWPENKEDHLVYADEESSNITDGRITPEPAVSNTEE-------PSTTSTASNYPDVLTRPS 130

  Fly   384 NNNNNNNNNVIETKTRRSELSAAAGGCGDSQSESDMNEYHDNGEGHDGLRPSHYNSNSNLEFYGN 448
            .:.::.|.:::|:.....:.|.::.....|...|.:.|..|:...||.      ::.|....:.:
Human   131 LHRSHLNFSMLESPALHCQPSTSSAFPIGSSGFSLVKEIKDSTSQHDD------DNISTTSGFSS 189

  Fly   449 LQSSKSIFNRSNTA--------AQQSHRNSTWSLNSLTQRRRFNASIYGSTS-ALSDSRLLSGSA 504
            ..|.|.|....||:        |::||..|..:..| :::..||.|.:|:.| :|.:|.:|.
Human   190 RASDKDITVSKNTSLPPLWSPEAERSHSLSQHTATS-SKKPAFNLSAFGTLSPSLGNSSILK--- 250

  Fly   505 SNSGSASASSSPFYQGRTTFGGNSGNNRLFSRSNLSSSAASSMLGLNSAGSSPA-HQLHASMTGG 568
                ::....||||.|:||:||.:...|   :|.|.          |:...:|. .|:.|.....
Human   251 ----TSQLGDSPFYPGKTTYGGAAAAVR---QSKLR----------NTPYQAPVRRQMKAKQLSA 298

  Fly   569 IGYGMKAVDMRPSDSGSLAETSVGQGGSKKPGTGLSNTTMRILNLLESYSTPLIDAKRMGSSIKE 633
            ..||:                             .|:|..|||..||..|:||.||||:.|.:..
Human   299 QSYGV-----------------------------TSSTARRILQSLEKMSSPLADAKRIPSIVSS 334

  Fly   634 HQSSRQQRQGTPATPYLRSTSASR-----------NVSVPNHINELAELRSNKLLVPTMQQLLER 687
            ..:|...|.|...|.:    .|.|           .:..|..:: :|..|| ....|::....|.
Human   335 PLNSPLDRSGIDITDF----QAKREKVDSQYPPVQRLMTPKPVS-IATNRS-VYFKPSLTPSGEF 393

  Fly   688 RRLHRVTQNSRDVVHSQNVRAGGENNQEKPK----PTAPYVAPIDQSANHTQHTNKMRSRLSHQT 748
            |:.::...|.....:.:|: ..|:|.:::..    |.....|....|:.......|||   ..:|
Human   394 RKTNQRIDNKCSTGYEKNM-TPGQNREQRESGFSYPNFSLPAANGLSSGVGGGGGKMR---RERT 454

  Fly   749 RNKETRTAEEEAPPPLDLPQISFPDMASA--PKFDLII-------KPTVPVVSKPSTTDPIQSSK 804
            |...::..|||......||::.....|.|  |.:.|.:       .|.:|.:|.|.|:..:.:..
Human   455 RFVASKPLEEERQGLTVLPKLISSSCAQAIIPSWPLKVLRLQEMEVPVLPKISLPITSSSLPTFN 519

  Fly   805 SSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSAISKPSKR---TFTFSEPTPLSNFQENC 866
            .|:..::|::             .:||.:..|..|...::.||..   .|.||.|. :.:.:.|.
Human   520 FSSPEITTSS-------------PSPINSSQALTNKVQMTSPSSTGSPMFKFSSPI-VKSTEANV 570

  Fly   867 IPKPKINRKYTFSAP-APLDDLRITNKQSQP----------TINGTPSSKEWECDTCMVRNKP-- 918
            :|...|.  :|||.| |...:|..::...:|          |:|.| :.|:...:.|....:|
Human   571 LPPSSIG--FTFSVPVAKTAELSGSSSTLEPIISSSAHHVTTVNST-NCKKTPPEDCEGPFRPAE 632

  Fly   919 --------EINKCVACETAK--PVASAAPVQAPLPPSTAAID--TQSFVGFGDRFKKSTTAWECD 971
                    :|.|.....:.|  .||:.....:|:..:..||.  :.|.:|||:.. |:.::|:||
Human   633 ILKEGSVLDILKSPGFASPKIDSVAAQPTATSPVVYTRPAISSFSSSGIGFGESL-KAGSSWQCD 696

  Fly   972 ACMLSNKAEASKCIAC----------------ETPRKTVAPKV--------NNFSPLITNAKSNE 1012
            .|:|.||...:|||||                |||.|:....:        :.|.|:|     ..
Human   697 TCLLQNKVTDNKCIACQAAKLSPRDTAKQTGIETPNKSGKTTLSASGTGFGDKFKPVI-----GT 756

  Fly  1013 WECSVCLVRNKVEVSKCVACESAKPGATM------------ALPATSNIAVATPSIITDGFGDRF 1065
            |:|..|||:||.|..||||||:.|||..:            |...|::.:..|.:..|.||||:|
Human   757 WDCDTCLVQNKPEAIKCVACETPKPGTCVKRALTLTVVSESAETMTASSSSCTVTTGTLGFGDKF 821

  Fly  1066 KKSATAWECDACMLSNKAEASKCIACETPRK-SSTPIANSSYPSINNNLPAGSGFDI-SFTRKAN 1128
            |:...:|||..|.:||.||.:||::|.:.:. ||.|.::||  ::..:||:|....: .|.:...
Human   822 KRPIGSWECSVCCVSNNAEDNKCVSCMSEKPGSSVPASSSS--TVPVSLPSGGSLGLEKFKKPEG 884

  Fly  1129 MWECQTCLVMNKSSDEECIACQT--PNSQARNSNSESALISSISSSSASFSGSLSRPSSRSSSGS 1191
            .|:|:.|||.||:...:|:||::  |.:::.....:::..||.|::|:||...:|..||..|...
Human   885 SWDCELCLVQNKADSTKCLACESAKPGTKSGFKGFDTSSSSSNSAASSSFKFGVSSSSSGPSQTL 949

  Fly  1192 TSTCGSV----CSGSIVSISSTTESAKALSAKKVPPKPDAGFQQLVAAQKTSTWECEACLAKNDM 1252
            ||| |:.    ..|..:.:||.:.|...:|......||...|:..|:::.
Human   950 TST-GNFKFGDQGGFKIGVSSDSGSINPMSEGFKFSKPIGDFKFGVSSES--------------- 998

  Fly  1253 SRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFGFSHVKEVVKPSVETTTTPAPTSAQFSFGF 1317
                       .||.....:...|        |:||.|  ..:..|   .:.||        |.|
Human   999 -----------KPEEVKKDSKNDN--------FKFGLS--SGLSNP---VSLTP--------FQF 1031

  Fly  1318 GQSNQGKDVADSKKTEAPKTFMFGVSKVEEPKTVSFGTG-IKETTATSSTEATAPTPAAAAPAPV 1381
            |.||.|:   :.||.|.||:...|         .||||| |..|.|.::|..|:...::
Human  1032 GVSNLGQ---EEKKEELPKSSSAG---------FSFGTGVINSTPAPANTIVTSENKSS------ 1078

  Fly  1382 QFVFKAPTTATTASSLTTTISTTSNA-----PAL-GGFSFG------APSSSSTVSSST------ 1428
               |...|..|.::|:......||.|     ||. ||||||      .||:|..|...|
Human  1079 ---FNLGTIETKSASVAPFTCKTSEAKKEEMPATKGGFSFGNVEPASLPSASVFVLGRTEEKQQE 1140

  Fly  1429 --TSTSA--------NPAAVKPMFSWSGAGSAVSSTSS---------------SQQPVAKAPTLG 1468
              ||||.        .....:|:||:..:.......||               |:|| ||| |..
Human  1141 PVTSTSLVFGKKADNEEPKCQPVFSFGNSEQTKDENSSKSTFSFSMTKPSEKESEQP-AKA-TFA 1203

  Fly  1469 FGVSSSTVTTTTTSTKVFAFTPASGLDPAAATSAPAAGAGFSFGSQSKPATTQNTGTFFFGQPTA 1533
            ||..:||......:..||:|...|    ::::|.||..||......|..::.....||.|||
Human  1204 FGAQTSTTADQGAAKPVFSFLNNS----SSSSSTPATSAGGGIFGSSTSSSNPPVATFVFGQ--- 1261

  Fly  1534 VAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGNWGEKKTDLTT 1598
                 .:||..||.||..|.|   |||.|...|..:..|..||.....||.:||.
Human  1262 -----SSNPVSSSAFGNTAES---STSQSLLFSQDSKLATTSSTGTAVTPFVFGP---------- 1308

  Fly  1599 FGASSGSGTTTTPSFGWSSNGDAAKSNSAAVGSAAV----PSSSASTMATPIFGSSSMFGPSSSS 1659
             ||||.:  |||..||:     .|.:.|::.||:.|    ||:.:   |:|.||:
Human  1309 -GASSNN--TTTSGFGF-----GATTTSSSAGSSFVFGTGPSAPS---ASPAFGA---------- 1352

  Fly  1660 NNTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTPAATAAAPLTNIF 1724
             |.|.|      ||.:...:...|.|        ||::.:|       .|..|..:..||.|  |
Human  1353 -NQTPT------FGQSQGASQPNPPG--------FGSISSS-------TALFPTGSQPAPPT--F 1393

  Fly  1725 GNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPGAFNFGGATAATPAASSAPFVFGSST 1789
            |..:. ::..||||.          .|:.:|            ||..|  ||.:||| |.|||||
Human  1394 GTVSS-SSQPPVFGQ----------QPSQSA------------FGSGT--TPNSSSA-FQFGSST 1432

  Fly  1790 NEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSHPRIFQFG--SSQPAANNQFGGA 1852
            .      :||||                     .|:|||      :|.||  ||.|||:.|..|
Human  1433 T------NFNFT---------------------NNSPSG------VFTFGANSSTPAASAQPSG- 1463

  Fly  1853 GGATNNSAGGMPMFNFSPGAPQMQSTPNANALFQFSATSTAPANIFAFNPPAAGNSAQSSQTARR 1917
                   :||.| ||.||.|..:.|  |...:|..|.||                      .:.|
Human  1464 -------SGGFP-FNQSPAAFTVGS--NGKNVFSSSGTS----------------------FSGR 1496

  Fly  1918 KIRAPVRR 1925
            ||:..|||
Human  1497 KIKTAVRR 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	113/499 (23%)
		RanBP2-type Zn finger	864..883	CDD:275375	7/19 (37%)
		zf-RanBP	903..931	CDD:279035	6/39 (15%)
		RanBP2-type Zn finger	907..926	CDD:275375	4/28 (14%)
		zf-RanBP	968..992	CDD:279035	15/39 (38%)
		RanBP2-type Zn finger	968..987	CDD:275375	10/18 (56%)
		zf-RanBP	1009..1038	CDD:279035	15/28 (54%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	11/18 (61%)
		zf-RanBP	1072..1097	CDD:279035	11/25 (44%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	10/18 (56%)
		zf-RanBP	1126..1155	CDD:279035	11/30 (37%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	8/18 (44%)
		ZnF_RBZ	1239..1261	CDD:197784	0/21 (0%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	0/18 (0%)
NUP153	NP_001265138.1	Nup153	113..660	CDD:285770	136/629 (22%)
		zf-RanBP	692..718	CDD:279035	12/25 (48%)
		RanBP2-type Zn finger	693..712	CDD:275375	10/18 (56%)
		zf-RanBP	754..782	CDD:279035	16/32 (50%)
		RanBP2-type Zn finger	757..776	CDD:275375	11/18 (61%)
		zf-RanBP	824..853	CDD:279035	11/28 (39%)
		RanBP2-type Zn finger	828..847	CDD:275375	10/18 (56%)
		zf-RanBP	882..911	CDD:279035	10/28 (36%)
		RanBP2-type Zn finger	886..905	CDD:275375	8/18 (44%)
		Nup_retrotrp_bd	1417..1506	CDD:287557	50/157 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158717
Domainoid	1	1.000	51	1.000	Domainoid score	I11649
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2834
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47406
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009548
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4945
SonicParanoid	1	1.000	-	-		X5439
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.030