DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup153 and POM121

DIOPT Version :9

Sequence 1:	NP_001097002.1	Gene:	Nup153 / 32630	FlyBaseID:	FBgn0061200	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_001374620.1	Gene:	POM121 / 9883	HGNCID:	19702	Length:	1249	Species:	Homo sapiens

Alignment Length:	1526	Identity:	360/1526 - (23%)
Similarity:	515/1526 - (33%)	Gaps:	514/1526 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 LSSSAASSMLGLN--SAGSSPAHQLHASMTGGIGYGMKAVDMRPSDS------------GSLAET 589
            |:..|.::..||:  ..||.|..          .:..||...||..|            .|....
Human    58 LTVGATAAWWGLSREPRGSRPLS----------SFVRKARHRRPLSSFVRKARHRRTLFASPLAK 112

  Fly   590 SVGQGGSKKPGTGLSNTTMRILNLLESY----STPLIDAKRMGSSIKEHQSSRQQRQGTPATPYL 650
            |...|...:|.|.|.......|.|:.||    ..|...|...|..:::....|...:..|.:|..
Human   113 STANGNLLEPRTLLEGPDPAELLLMGSYLGKPGPPQPAAAPEGQDLRDRPGRRPPARPAPRSPPP 177

  Fly   651 RS-----------TSASRNV--SVPNHINELAELRSNKL-------LVPTMQQLLERRR--LHRV 693
            ||           |..:.:|  |:|..:     ||.::.       .:|....:..|||  :|:.
Human   178 RSPPPRSPPPSPPTHRAHHVYPSLPTPL-----LRPSRRPSPRDCGTLPNRFVITPRRRYPIHQA 237

  Fly   694 TQNSRDVV--------HSQNVRAGGENNQEKPKPTAPYVAPIDQSANHTQHTNK-MRSRLSHQTR 749
            ..:...|:        |.:.| ....|::....|....:||.|:..:.:....: :.|.||..:.
Human   238 QYSCLGVLPTVCWNGYHKKAV-LSPRNSRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSS 301

  Fly   750 N------KET-----------RTAEEEAPPPLDLPQISFPDMASAPK-----------FDLIIKP 786
            |      |||           ||.|||       .||......:..:           |:.::..
Human   302 NAPDPCAKETVLSALKEKEKKRTVEEE-------DQIFLDGQENKRRRHDSSGSGHSAFEPLVAN 359

  Fly   787 TVPV--VSKPSTTDPIQSSKSSNTNLSTTNSKQMPNFLANPQPAAPIVNFAANGNVSA------I 843
            .||.  |.||.:.....:|:||:.:|:..:.....:.|.... |:.|.:.:.|...|:      |
Human   360 GVPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAY-ASGIPSSSRNAITSSYSSTRGI 423

  Fly   844 SKPSKRTFTFSEPTPLSNFQENCIPKPKINRKYTFSAPAPLDDLRITNKQSQPTINGTPSSKEWE 908
            |:..||....|.|                     ||:||        :.:||     ||.
Human   424 SQLWKRNGPSSSP---------------------FSSPA--------SSRSQ-----TPE----- 449

  Fly   909 CDTCMVRNKPEINKCVACETAKPVASAAPVQAPLPPSTAAIDTQSFVGFGDRFKKSTTAWECDAC 973
                  |...:|.:...|..:   :|:.|:.|                  ||..:...|
Human   450 ------RPAKKIREEELCHHS---SSSTPLAA------------------DRESQGEKA------ 481

  Fly   974 MLSNKAEASKCIACETPRKTVAPKVNNFSPLITNAKSNEWECSVCLVRNKVEVSKCVACESAKPG 1038
                        |..||||    |.|:.|.....:....        :.||::.      .::.|
Human   482 ------------ADTTPRK----KQNSNSQSTPGSSGQR--------KRKVQLL------PSRRG 516

  Fly  1039 ATMALPATSNIAVATPSIITDGFGDRFKKSATAWECDACMLSNKAEASKCIACETPRKSSTPIAN 1103
            ..:.||....:..:    ||....|..||::..|...|  |.:|::|:.....|||     ||
Human   517 EQLTLPPPPQLGYS----ITAEDLDLEKKASLQWFNQA--LEDKSDAASNSVTETP-----PI-- 568

  Fly  1104 SSYPSINNNLPAGSGFDISFTRKANMWECQTCLVMNKSSDEECIACQTPNSQARNSNSESALISS 1168
             :.||....|||.:                              ....|.|..  :.|.:.|:.|
Human   569 -TQPSFTFTLPAAA------------------------------PASPPTSLL--APSTNPLLES 600

  Fly  1169 ISSSSASFSGSLSRPSSRSSSGSTSTCGSVCSGSIVSISSTTESAKALSAKKVPP-KPDAGFQQL 1232
            :.....    ..|.|....|:|:.:|                   :|||..|.|. .|..|..|
Human   601 LKKMQT----PPSLPPCPESAGAATT-------------------EALSPPKTPSLLPPLGLSQ- 641

  Fly  1233 VAAQKTSTWECEACLAKNDMSRKTCICCEQMMPEAFNPAATTANSAASSVPKFRFGFSHVKEVVK 1297
                                              :..|....:.|..|..|....|.     :..
Human   642 ----------------------------------SGPPGLLPSPSFDSKPPTTLLGL-----IPA 667

  Fly  1298 PS-VETTTTPAPTSAQFSFGFGQSNQGKDVADSKKTEAPK-TFMFGVSKVEEPKTVSFGTGIKET 1360
            || |..|.|.||.:.|      .....|..|.|..:.||| :|:||
Human   668 PSMVPATDTKAPPTLQ------AETATKPQATSAPSPAPKQSFLFG------------------- 707

  Fly  1361 TATSSTEATAPTPAAAAPAPVQF--VFKAP----------------TTATTASSLTTTISTTSNA 1407
              |.:|..::|...||:.||..|  :|.||                .||.::|||.||.|||:..
Human   708 --TQNTSPSSPAAPAASSAPPMFKPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPT 770

  Fly  1408 --PALGGFSFGAPSS---SSTVSSSTTSTSANPAAVKPMFSWSGAGSAVS-----STSSSQQPVA 1462
              |...  |.|.|:|   .:.....||:.:..|....|:|  :|..||.|     :::|.....|
Human   771 FQPVFS--SMGPPASVPLPAPFFKQTTTPATAPTTTAPLF--TGLASATSAVAPITSASPSTDSA 831

  Fly  1463 KAPTLGFGVS--SSTVTTTTTSTKVFAFTP-ASGLDPAAATS-APAAGAGFSFGSQSKPATTQNT 1523
            ..|..|||::  ||:..:|||||...|..| ..|...|:|.| .||.|:.|.||......||...
Human   832 SKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTV 896

  Fly  1524 GTFFFGQPTAVAPATPTNPSVSSIFGAPATSTTASTSVSATTSTSTANAIASSFAPTSTPQLFGN 1588
            .||.....|||..||.::.:..|.||     :|.:||..||:|..|.     :|:.||||
Human   897 TTFSQSLHTAVPTATSSSAADFSGFG-----STLATSAPATSSQPTL-----TFSNTSTP----- 946

  Fly  1589 WGEKKTDLTTFGASSGS------GTTTTPSFGWSSNGDAAKSNSAAVGSAAVPSSSASTMATPIF 1647
                 |....||:|:.|      |....|:||            ||.|.   |..:|.....|.|
Human   947 -----TFNIPFGSSAKSPLPSYPGANPQPAFG------------AAEGQ---PPGAAKPALAPSF 991

  Fly  1648 GSSSMFGPSSSSNNTTSTSTTSLPFGSAATTAATTPAGGNAALTGLFGNVGNSLAGVGAPVATTP 1712
            |||..||                  .|||..||.|||..:.                   :...|
Human   992 GSSFTFG------------------NSAAPAAAPTPAPPSM-------------------IKVVP 1019

  Fly  1713 AATAAAPLTNIFGNPTPVAAAAPVFGSGSTIPSAGFGAPAAAAPLAAPALPG--AFNFG------ 1769
             |....|:..|||..|..|     ||..:|  ::.|||||:    :.||..|  |..||
Human  1020 -AYVPTPIHPIFGGATHSA-----FGLKAT--ASAFGAPAS----SQPAFGGSTAVFFGAATSSG 1072

  Fly  1770 -GATAATPAASSAPFVFGSSTNEPLAKPSFNFTGSAASSTAPAPAFNFTANTAATNNPSGGDSHP 1833
             |||..|.::.|:..||||:|..|     |.|.|||    |||.:.:|..|.|.    .|..:..
Human  1073 FGATTQTASSGSSSSVFGSTTPSP-----FTFGGSA----APAGSGSFGINVAT----PGSSTTT 1124

  Fly  1834 RIFQFGSSQ---PAANNQFGGAGGATNNSAG--GMPMFNFSPGAPQMQSTPNANALFQFSATSTA 1893
            ..|.||:.|   .|.:..|  |||...|:.|  |..    :|.|..:.||..:..:|..:||.|
Human  1125 GAFSFGAGQSGSTATSTPF--AGGLGQNALGTTGQS----TPFAFNVSSTTESKPVFGGTATPT- 1182

  Fly  1894 PANIFAFNPPAAGNSAQSSQTARRKIRAPVR 1924
                |..|.||.|.....|..:.....||.:
Human  1183 ----FGLNTPAPGVGTSGSSLSFGASSAPAQ 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup153	NP_001097002.1	Nup153	<458..910	CDD:285770	92/455 (20%)
		RanBP2-type Zn finger	864..883	CDD:275375	3/18 (17%)
		zf-RanBP	903..931	CDD:279035	3/27 (11%)
		RanBP2-type Zn finger	907..926	CDD:275375	2/18 (11%)
		zf-RanBP	968..992	CDD:279035	3/23 (13%)
		RanBP2-type Zn finger	968..987	CDD:275375	0/18 (0%)
		zf-RanBP	1009..1038	CDD:279035	2/28 (7%)
		RanBP2-type Zn finger	1013..1032	CDD:275375	2/18 (11%)
		zf-RanBP	1072..1097	CDD:279035	8/24 (33%)
		RanBP2-type Zn finger	1072..1091	CDD:275375	5/18 (28%)
		zf-RanBP	1126..1155	CDD:279035	1/28 (4%)
		RanBP2-type Zn finger	1130..1149	CDD:275375	0/18 (0%)
		ZnF_RBZ	1239..1261	CDD:197784	0/21 (0%)
		RanBP2-type Zn finger	1241..1260	CDD:275375	0/18 (0%)
POM121	NP_001374620.1	Required for targeting to the nucleus and nuclear pore complex	1..285		49/242 (20%)
		Cisternal side. /evidence=ECO:0000255	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Pore side. /evidence=ECO:0000255	56..1249		360/1526 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..220		17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..530		58/320 (18%)
		POM121	321..552	CDD:405826	65/346 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..776		57/263 (22%)
		PHA03247	<627..990	CDD:223021	125/468 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..986		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1226..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23193
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030